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Displaying record number 60614

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HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(127-135)
Epitope	GDIYKRWII	Epitope Alignment
		Show epitope variants
Subtype	B, C
Species (MHC/HLA)	human(B*08, B*08:01, B*40)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Subtype-specific substitutions in two HIV Gag regions (fragments F1, amino acids (aa) 5-46, and F2 aa 100-143) result in novel adaptations that affect epitope processing efficiency. Consequent low epitope abundance is associated with weak T cell response and greater immune escape and therefore with disease state. Conversely, epitopes from these regions when restricted by certain rare HLA I alleles, are associated with greater production and resulting CTL response, therefore delayed disease progression.
• Most epitopes were found to be processed as precursors with N-terminal extensions beyond the optimal epitope. Only 4 epitopes in this region were associated with delayed progression - HLA-B*5701/03-restricted IW9 (ISPRTLNAW), KF11 (KAFSPEVIPMF), TW10 (TSTLQEQIGW) and HLA-B*2705-restricted KK10 (KRWIILGLNK).
• Regardless of ethnic group, white or African, a significant three-way interaction was found between HLA allelic frequency, epitope yield and ethnicity for epitopes of N-terminal fragment F1 (NF1) and C-terminal as well as middle F2 (CF2 and MF2). C-terminal F1 (CF1) epitope yields however, showed a significant difference between ethnic groups. Also, for identical HLA-mediated selection pressure in both Africans and whites, HIV-C had a lower concentration than HIV-B, especially at lower HLA allelic frequencies.
• Epitope GDIYKRWII, GI-9, from fragment NF2-MF2, restricted by HLA-B*08, B*801, B*40, had no determined natural processed epitope forms for subtypes B or C. When studied from fragment CF2, natural processed form was TSNPPIPVGDIYKRWI, with 100% processed 4h post-constitutive proteasome or immuno-proteasomes.

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.

Displaying record number 254

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HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(259-267 SF2)
Epitope	GDIYKRWII	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B*08:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• GDIYKRWII specific CTL clone also recognized GEIYKRWII.

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.