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Displaying record number 55156

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HXB2 Location	Nef(83-91) DNA(9043..9069)	Nef Epitope Map
Author Location
Epitope	GAFDLSFFL?	Epitope Alignment
Epitope Name	GL9
Species (MHC/HLA)	human(A*02:05)
Immunogen	HIV-1 infection
Country	South Africa, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords	memory cells

Notes

• Cohorts of HIV-infected subjects from the US and South Africa were screened for CD8+ EliSpot responses. Tetramer assays were performed for 13 frequently targeted HIV epitopes and compared to Flu, vaccinia, and EBV epitopes assayed in non-HIV-infected subjects. HIV tetramer+ CD8 T cells expressed less CD127, and this reduction was pervasive across all epitopes and alleles tested. These results indicated impaired HIV-specific memory CD8 T cell differentiation, regardless of level of control of viremia, epitopes targeted, or HLA alleles.

References

Wherry2006 E John Wherry, Cheryl L. Day, Rika Draenert, Joseph D. Miller, Photini Kiepiela, Tonia Woodberry, Christian Brander, Marylyn Addo, Paul Klenerman, Rafi Ahmed, and Bruce D. Walker. HIV-Specific CD8 T Cells Express Low Levels of IL-7Ralpha: Implications for HIV-Specific T Cell Memory. Virology, 353(2):366-373, 30 Sep 2006. PubMed ID: 16860834. Show all entries for this paper.