HIV molecular immunology database
Found 13 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | FK10 | |
Species (MHC/HLA) | human(B*18) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression |
Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(161-170) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(B18) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(293-302) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B18) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | FK10 | |
Subtype | B | |
Species (MHC/HLA) | human(B18) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | dynamics, characterizing CD8+ T cells, chronic infection |
Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Subtype | B, D | |
Species (MHC/HLA) | human, macaque(B18) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(161-170) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*18:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion |
Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24( subtype B, D) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Subtype | B, D | |
Species (MHC/HLA) | human(B*18:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(161-170 HXB2) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | FK10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*18:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition, optimal epitope |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24( subtype B, D) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Subtype | B, D | |
Species (MHC/HLA) | human(B*18:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ogg1998b G. S. Ogg, T. Dong, P. Hansasuta, L. Dorrell, J. Clarke, R. Coker, G. Luzzi, C. Conlon, A. P. McMichael, and S. Rowland-Jones. Four Novel Cytotoxic T-Lymphocyte Epitopes in the Highly Conserved Major Homology Region of HIV-1 Gag, Restricted through B*4402, B*1801, A*2601, B*70 (B*1509). AIDS, 12:1561-1563, 1998. PubMed ID: 9727585. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(161-170) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | FK10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*18:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection |
Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | B18-FK10(p24) | |
Species (MHC/HLA) | human(B27) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(293-302) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Epitope Name | FK10 | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | acute/early infection, mutation acquisition, viral fitness and reversion, viral replication |
Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(293-302) p24(161-170) DNA(1666..1695) |
Gag Epitope Map |
---|---|---|
Author Location | p24(293-302) | |
Epitope |
FRDYVDRFYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.