HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 59304

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name FK10
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 1453

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(161-170)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1680

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(293-302)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Show epitope variants
Species (MHC/HLA) human(B18)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 55497

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name FK10
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords dynamics, characterizing CD8+ T cells, chronic infection

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 52425

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Subtype B, D
Species (MHC/HLA) human, macaque(B18)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 59075

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(161-170)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Subtype B
Species (MHC/HLA) human(B*18:01)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 310

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24( subtype B, D)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Subtype B, D
Species (MHC/HLA) human(B*18:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54148

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(161-170 HXB2)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name FK10
Subtype B
Species (MHC/HLA) human(B*18:01)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 309

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24( subtype B, D)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Subtype B, D
Species (MHC/HLA) human(B*18:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ogg1998b G. S. Ogg, T. Dong, P. Hansasuta, L. Dorrell, J. Clarke, R. Coker, G. Luzzi, C. Conlon, A. P. McMichael, and S. Rowland-Jones. Four Novel Cytotoxic T-Lymphocyte Epitopes in the Highly Conserved Major Homology Region of HIV-1 Gag, Restricted through B*4402, B*1801, A*2601, B*70 (B*1509). AIDS, 12:1561-1563, 1998. PubMed ID: 9727585. Show all entries for this paper.


Displaying record number 58140

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(161-170)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name FK10
Subtype B
Species (MHC/HLA) human(B*18:01)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 54353

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name B18-FK10(p24)
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 62304

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(293-302)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Epitope Name FK10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords acute/early infection, mutation acquisition, viral fitness and reversion, viral replication

Notes

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.


Displaying record number 62814

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HXB2 Location Gag(293-302)
p24(161-170)
DNA(1666..1695)
Gag Epitope Map
Author Location p24(293-302)
Epitope FRDYVDRFYK Epitope Alignment
FRDYVDRFYK epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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