HIV molecular immunology database
Found 15 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Epitope Name | FR10 | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(66-75) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | F10LR | |
Species (MHC/HLA) | human, transgenic mouse(B*07) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design |
Vaccine type | polyepitope |
---|---|
Vaccine strain | multiple epitope immunogen |
Vaccine component | HIV-1 |
Cardinaud2009 Sylvain Cardinaud, Romain Bouziat, Pierre-Simon Rohrlich, Sophie Tourdot, Laurence Weiss, Pierre Langlade-Demoyen, Anne Burgevin, Susana Fiorentino, Peter van Endert, and François A. Lemonnier. Design of a HIV-1-Derived HLA-B07.02-Restricted Polyepitope Construct. AIDS, 23(15):1945-1954, 24 Sep 2009. PubMed ID: 19644347. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07, B*35) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77 LAI) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77 LAI) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( subtype B) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), escape |
Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77 SF2) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-76) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(68-77) | |
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Epitope Name | FR10 | |
Species (MHC/HLA) | human(B*81) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(68-77) DNA(8998..9027) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FPVTPQVPLR
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 014A-005: A*25:01, A*30:02, B*07:02, B*18:01, C*07:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | canarypox prime with gp120 boost |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | Gag-Pol, gp120, gp41 |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.