HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 61033

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Show epitope variants
Epitope Name FL9
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords escape, mutation acquisition, HLA associated polymorphism

Notes

References

Carlson2016 Jonathan M. Carlson, Victor Y. Du, Nico Pfeifer, Anju Bansal, Vincent Y. F. Tan, Karen Power, Chanson J. Brumme, Anat Kreimer, Charles E. DeZiel, Nicolo Fusi, Malinda Schaefer, Mark A. Brockman, Jill Gilmour, Matt A. Price, William Kilembe, Richard Haubrich, Mina John, Simon Mallal, Roger Shapiro, John Frater, P. Richard Harrigan, Thumbi Ndung'u, Susan Allen, David Heckerman, John Sidney, Todd M. Allen, Philip J. R. Goulder, Zabrina L. Brumme, Eric Hunter, and Paul A. Goepfert. Impact of Pre-Adapted HIV Transmission. Nat. Med., 22(6):606-613, Jun 2016. PubMed ID: 27183217. Show all entries for this paper.


Displaying record number 59045

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Epitope Name FL9-Nef
Subtype B, C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 56198

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(94-)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B*07:02)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 59249

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(68-76)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Patient MHC/HLA Subject 8: A*02:01, A*24:02, B*07:02, B*40:01, C*03:04, C*07:02
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords dynamics, acute/early infection, dendritic cells

Notes

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Displaying record number 61171

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(68-76)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Show epitope variants
Epitope Name FL9
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 54188

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(103-111)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Experimental methods Other
Keywords HLA associated polymorphism

Notes

References

Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.


Displaying record number 53874

Download this epitope record as JSON.

HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(68-76)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Patient MHC/HLA A*03, A*24, B*35, B*40
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, variant cross-reactivity, superinfection

Notes

References

Yang2005 Otto O. Yang, Eric S. Daar, Beth D. Jamieson, Arumugam Balamurugan, Davey M. Smith, Jacqueline A. Pitt, Christos J. Petropoulos, Douglas D. Richman, Susan J. Little, and Andrew J. Leigh Brown. Human Immunodeficiency Virus Type 1 Clade B Superinfection: Evidence for Differential Immune Containment of Distinct Clade B Strains. J. Virol., 79(2):860-868, Jan 2005. PubMed ID: 15613314. Show all entries for this paper.


Displaying record number 960

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(72-80 SF2)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 961

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location ( SF2)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.


Displaying record number 1418

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(66-74)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 962

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(72-80 SF2)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 54311

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(68-76)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 1343

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(72-80)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000a H. Tomiyama, S. Oka, G. S. Ogg, S. Ida, A. J. McMichael, and M. Takiguchi. Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. AIDS, 14(13):2049-51, 8 Sep 2000. PubMed ID: 10997412. Show all entries for this paper.


Displaying record number 56218

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location  
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Subtype C
Species (MHC/HLA) human(B*35:01, B7)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression, optimal epitope

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 55974

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Show epitope variants
Epitope Name FL9(Nef)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56541

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Epitope Name Nef94
Subtype B
Species (MHC/HLA) human(B7)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 56095

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Epitope Name Nef1124
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 56520

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Epitope Name Nef94
Subtype A, B, C, D
Species (MHC/HLA) human, mouse(B7 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 59390

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HXB2 Location Nef(68-76)
DNA(8998..9024)
Nef Epitope Map
Author Location Nef(68-76)
Epitope FPVRPQVPL Epitope Alignment
FPVRPQVPL epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH078: A*01, A*30, B*42, B*81, C*17, C*18
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords dynamics, escape, superinfection

Notes

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.


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