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Displaying record number 61913

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HXB2 Location	Pol(155-165) Protease(99)-RT(10) DNA(2547..2579)	Pol Epitope Map
Author Location	Pol(155-165)
Epitope	FPISPIETVPV	Epitope Alignment
Epitope Name	FV11
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-115: B*54:01; KI-160: B*54:01; KI-627: B*54:01; KI-119: B*54:01; KI-172: B*54:01
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords	optimal epitope

Notes

• Multiple overlapping peptides across Pol 155-165 can be presented and recognized as well as cross-recognized by CTL. B*5401-restricted CTL from B*5401+ patients recognized any of 9-, 10- 11-mer Pol peptides, with the 9mer, FPISPIETV, being optimal.
• FV9 and FP10 are presented by HLA-B*5401. FV11 may also be presented.

References

Hashimoto2012 Masao Hashimoto, Tomohiro Akahoshi, Hayato Murakoshi, Naoki Ishizuka, Shinichi Oka, and Masafumi Takiguchi. CTL Recognition of HIV-1-Infected Cells via Cross-Recognition of Multiple Overlapping Peptides from a Single 11-Mer Pol Sequence. Eur. J. Immunol., 42(10):2621-2631, Oct 2012. PubMed ID: 22740036. Show all entries for this paper.