Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55524

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HXB2 Location	Pol(155-164) Protease(99)-RT(9) DNA(2547..2576)	Pol Epitope Map
Author Location	Pol(155-164)
Epitope	FPISPIETVP	Epitope Alignment
Epitope Name	FP10
Subtype	B
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02:06, B*48:01, B*54:01
Country	Japan
Experimental methods	Chromium-release assay, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Asian-expressed HLA-B*5401-restricted epitopes were identified using overlapping-peptide methods and characterized. 5 epitopes from Pol and Nef induced CTL responses that killed target cells in more than 25% of B*5401-carrying tested patients.
• 7 peptides from Pol and Nef are listed in Fig. 2 as candidates for B*5401 restriction. No Gag-specific epitopes were identified in this study from the patient whose lymphocytes were screened.
• FPISPIETVP was defined as an HLA-B*5401 restricted optimal epitope, using truncated peptides.

References

Kitano2008 Mitsutaka Kitano, Naoki Kobayashi, Yuka Kawashima, Tomohiro Akahoshi, Kiyoshi Nokihara, Shinichi Oka, and Masafumi Takighuchi. Identification and Characterization of HLA-B*5401-Restricted HIV-1-Nef and Pol-Specific CTL Epitopes. Microbes Infect, 10(7):7647-72, Jun 2008. PubMed ID: 18538615. Show all entries for this paper.

Displaying record number 61912

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HXB2 Location	Pol(155-164) Protease(99)-RT(9) DNA(2547..2576)	Pol Epitope Map
Author Location	Pol(155-164)
Epitope	FPISPIETVP	Epitope Alignment
Epitope Name	FP10
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	KI-115: B*54:01; KI-160: B*54:01; KI-627: B*54:01; KI-119: B*54:01; KI-172: B*54:01
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords	optimal epitope

Notes

• Multiple overlapping peptides across Pol 155-165 can be presented and recognized as well as cross-recognized by CTL. B*5401-restricted CTL from B*5401+ patients recognized any of 9-, 10- 11-mer Pol peptides, with the 9mer, FPISPIETV, being optimal.
• FV9 and FP10 are presented by HLA-B*5401. FV11 may also be presented.

References

Hashimoto2012 Masao Hashimoto, Tomohiro Akahoshi, Hayato Murakoshi, Naoki Ishizuka, Shinichi Oka, and Masafumi Takiguchi. CTL Recognition of HIV-1-Infected Cells via Cross-Recognition of Multiple Overlapping Peptides from a Single 11-Mer Pol Sequence. Eur. J. Immunol., 42(10):2621-2631, Oct 2012. PubMed ID: 22740036. Show all entries for this paper.