Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 781

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HXB2 Location	gp160(376-383) gp120(376-383) DNA(7350..7373)	gp160 Epitope Map
Author Location	gp120(376-383)
Epitope	FNCGGEFF	Epitope Alignment
Species (MHC/HLA)	human(Cw4)
Immunogen	HIV-1 infection
Country	Gambia
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), variant cross-reactivity, HIV-2

Notes

• CTL responses in seronegative highly HIV-exposed African female sex workers in Gambia and Nairobi were studied -- these women had no delta 32 deletion in CCR5.
• In Gambia there is exposure to both HIV-1 and HIV-2. CTL responses to B*35 epitopes in exposed, uninfected women are cross-reactive.
• HIV-2: TNCRGEFL -- no cross-reactivity Johnson1993
• Database note: First author "Rowland-Jones" is also found as "RowlandJones" on annotated papers in this database.

References

Johnson1993 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Recognition of a Highly Conserved Region of Human Immunodeficiency Virus Type 1 gp120 by an HLA-Cw4-Restricted Cytotoxic T-Lymphocyte Clone. J. Virol., 67:438-445, 1993. The epitope sequence FNCGGEFF stimulates CTL response; the natural variants FNCRGEFF (SF2), TNCRGEFL (ROD) and LNCGGEFF (NDK) do not serve as epitopes. This was the first report of an HIV antigen specific target cells restricted by an HLA-C molecule, Cw4. PubMed ID: 7677956. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.

Displaying record number 55138

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HXB2 Location	gp160(376-383) gp120(376-383) DNA(7350..7373)	gp160 Epitope Map
Author Location	gp120(376-383)
Epitope	FNCGGEFF	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(Cw4)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

• Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
• Present in 147/200 Brazilian HIV sequences; a common variant is FNCrGEFF.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.