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Displaying record number 57434

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HXB2 Location	Tat(38-47) DNA(5942..5971)	Tat Epitope Map
Author Location	Tat( B*1501)
Epitope	FMTKGLGISY	Epitope Alignment
		Show epitope variants
Epitope Name	FY10, MY9
Subtype	B
Species (MHC/HLA)	human(B*15:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Chromium-release assay
Keywords	escape, acute/early infection

Notes

• 3 subjects with acute HIV infection were studied longitudinally by 454-ultra deep-sequencing of 4 HIV-1 epitope regions that have early recognition and escape. Over 50 variant forms of each CTL epitope targeted during the first 3-6 weeks of infection were found, i.e. 7-25 times more than variation in the control V3 region of Env, at earlier times. In very early infection, reversions were seen where immune pressure was considerable but they were absent outside epitopes. A strong case was made for establishment of infection via a single virus.
• All 3 subjects' epitopes have been tested in previous publications.
• In patient SUMA, 3 escape lineages come from transmitted Tat region FY16, FHCQVCFMTKGLGISY, containing this epitope, MY9 or FY10: lHCQVCFMkKGLGISY; FHCQVCFMkKGLGISY; FHCQdCFMkKGLGISY. The rate of accumulation/loss in FY16, is -0.14. Selection is estimated to have begun at day 10 postinfection in FY10, but escape accumulated very slowly.

References

Fischer2010 Will Fischer, Vitaly V. Ganusov, Elena E. Giorgi, Peter T. Hraber, Brandon F. Keele, Thomas Leitner, Cliff S. Han, Cheryl D. Gleasner, Lance Green, Chien-Chi Lo, Ambarish Nag, Timothy C. Wallstrom, Shuyi Wang, Andrew J. McMichael, Barton F. Haynes, Beatrice H. Hahn, Alan S. Perelson, Persephone Borrow, George M. Shaw, Tanmoy Bhattacharya, and Bette T. Korber. Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing. PLoS One, 5(8):e12303, 2010. PubMed ID: 20808830. Show all entries for this paper.