HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 90 matching records:

Displaying record number 57521

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 53722

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name BRU
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2, B8)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 1838

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Ostrowski2000 M. A. Ostrowski, S. J. Justement, L. Ehler, S. B. Mizell, S. Lui, J. Mican, B. D. Walker, E. K. Thomas, R. Seder, and A. S. Fauci. The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses. J. Immunol., 165(11):6133-41, 1 Dec 2000. URL: http://www.jimmunol.org/cgi/content/full/165/11/6133. PubMed ID: 11086046. Show all entries for this paper.


Displaying record number 59667

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62128

HXB2 Location Nef(90-97) Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B*08-FL8
Species (MHC/HLA) human(B*08)
Immunogen computer prediction
Country Argentina
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 1015

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97 LAI)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Patient MHC/HLA A1, B7, B8, Cw*0701, Cw*0702
Experimental methods Chromium-release assay, HLA binding
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.


Displaying record number 1800

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 1993

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name Nef-FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 55086

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef( SF2)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords TCR usage

References

Meyer-Olson2006 Dirk Meyer-Olson, Kristen W. Brady, Melissa T. Bartman, Kristin M. O'Sullivan, Brenna C. Simons, Joseph A. Conrad, Coley B. Duncan, Shelly Lorey, Atif Siddique, Rika Draenert, Marylyn Addo, Marcus Altfeld, Eric Rosenberg, Todd M. Allen, Bruce D. Walker, and Spyros A. Kalams. Fluctuations of Functionally Distinct CD8+ T-Cell Clonotypes Demonstrate Flexibility of the HIV-Specific TCR Repertoire. Blood, 107(6):2373-2383, 15 Mar 2006. PubMed ID: 16322475. Show all entries for this paper.


Displaying record number 55277

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.


Displaying record number 55333

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-96)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords rate of progression, acute/early infection, memory cells

Notes

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.


Displaying record number 55750

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A2, B49, B8, Cw7
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition

Notes

References

Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.


Displaying record number 56407

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 56757

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 57578

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) (B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 57911

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 58007

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing, escape

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58277

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58538

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58544

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B8-FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 58782

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype A, B, C, CRF01_AE, D, F, G, H
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization
Keywords subtype comparisons, epitope processing

Notes

References

Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.


Displaying record number 58800

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B*08-FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods Other, Tetramer binding
Keywords  

Notes

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.


Displaying record number 59665

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61239

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 61634

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B08-FL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 55006

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FLK
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 53825

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, B*0801
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords escape, acute/early infection

Notes

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 60941

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA 71101: A*0101, A*0301, B*0801, B*3503, Cw*0401, Cw*0701; 44149: A*0101, A*2401, B*0701, B*0801, Cw*0701, Cw*0702; 67200: A*0101, A*2401, B*0801, B*5701, Cw*0602, Cw*0701; 32645: A*0101, A*0201, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61628

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B*08-FL8
Subtype C
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Koofhethile2016 Catherine K. Koofhethile, Zaza M. Ndhlovu, Christina Thobakgale-Tshabalala, Julia G. Prado, Nasreen Ismail, Zenele Mncube, Lungile Mkhize, Mary van der Stok, Nonhlanhla Yende, Bruce D. Walker, Philip J. R. Goulder, and Thumbi Ndung'u. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J. Virol., 90(15):6818-6831, 1 Aug 2016. PubMed ID: 27194762. Show all entries for this paper.


Displaying record number 55171

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.


Displaying record number 58854

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country Canada
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.


Displaying record number 58985

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 54074

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location ( C consensus)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype C
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 53190

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*0801, B*5701, Cw*0602, Cw*0701; A*0101, A*0201, B*0801, B*5701, Cw*0602, Cw*0701; A2, A*2402, B*0801, B15, Cw12, Cw7; A*0101, A*0201, B*0801, B*5701, Cw*0602, Cw*0701
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords rate of progression, escape, TCR usage, characterizing CD8+ T cells

Notes

References

Dong2004 Tao Dong, Guillaume Stewart-Jones, Nan Chen, Philippa Easterbrook, Xiaoning Xu, Laura Papagno, Victor Appay, Michael Weekes, Chris Conlon, Celsa Spina, Susan Little, Gavin Screaton, Anton van der Merwe, Douglas D. Richman, Andrew J. McMichael, E. Yvonne Jones, and Sarah L. Rowland-Jones. HIV-Specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor. J. Exp. Med., 200(12):1547-1557, 20 Dec 2004. PubMed ID: 15596521. Show all entries for this paper.


Displaying record number 59178

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name nef 90-97
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 53287

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location ( C consensus)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype C
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 57954

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Subtype A, B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 1016

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97 LAI)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57100

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97 DU422)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 57376

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name B8-FL8 wt
Species (MHC/HLA) human(B*0801)
Immunogen in vitro stimulation or selection, peptide-HLA interaction
Country United States
Experimental methods Other
Keywords binding affinity, escape

Notes

References

Yang2010 Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, and Xu G. Yu. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS One, 5(12):e15084, 2010. PubMed ID: 21170342. Show all entries for this paper.


Displaying record number 54607

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype C
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords rate of progression

Notes

References

Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.


Displaying record number 61994

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 57807

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 54751

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 59669

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59668

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59666

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52853

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97 B consensus)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords dynamics, escape, mutation acquisition

Vaccine Details

Vaccine type adeno-associated virus (AAV)
Vaccine component gp120

Notes

References

Brainard2004 Diana M. Brainard, William G. Tharp, Elva Granado, Nicholas Miller, Alicja K. Trocha, Xiang-Hui Ren, Brian Conrad, Ernest F. Terwilliger, Richard Wyatt, Bruce D. Walker, and Mark C. Poznansky. Migration of Antigen-Specific T Cells away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol., 78(10):5184-5193, May 2004. PubMed ID: 15113900. Show all entries for this paper.


Displaying record number 53156

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) (B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, review, escape, characterizing CD8+ T cells

Notes

References

daSilva2003 Jack da Silva. The Evolutionary Adaptation of HIV-1 to Specific Immunity. Curr. HIV Res., 1(3):363-371, Jul 2003. PubMed ID: 15046259. Show all entries for this paper.


Displaying record number 53187

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords HAART, ART, memory cells, characterizing CD8+ T cells

Notes

References

Daniel2004 Nathalie Daniel, Bénédicte Charmeteau, Sophie Grabar, Gilles Pialoux, Dominique Salmon, Nelly Bonilla, Marion Dupuis, Christelle Troadec, Willy Rozenbaum, Hanne Gahéry-Ségard, Jean-Gérard Guillet, and Muriel Andrieu. Use of Well-Defined HIV-Derived Epitopes to Evaluate CD4+ and CD8+ T Cell Responses in Patients with Chronic HIV-1 Infection Treated with HAART. AIDS Res. Hum. Retroviruses, 20(8):827-835, Aug 2004. PubMed ID: 15320987. Show all entries for this paper.


Displaying record number 53338

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding
Keywords immunodominance, acute/early infection, characterizing CD8+ T cells

Notes

References

Lichterfeld2004 Mathias Lichterfeld, Daniel E. Kaufmann, Xu G. Yu, Stanley K. Mui, Marylyn M. Addo, Mary N. Johnston, Daniel Cohen, Gregory K. Robbins, Eunice Pae, Galit Alter, Alysse Wurcel, David Stone, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-Induced HIV-1-Specific CD4+ T Cells. J. Exp. Med., 200(6):701-12, Sep 20 2004. PubMed ID: 15381726. Show all entries for this paper.


Displaying record number 53359

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location ( B consensus)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B62, B8, Cw10, Cw7; A11, A29, B44, B8, Cw4, Cw7; A25, A32, B14, B8, Cw7, Cw8; A1, A3, B14, B8, Cw7, Cw8
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53405

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 53542

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 1018

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.

Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.


Displaying record number 53782

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 54172

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97 HXB2)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1365: A*0101, A*0201, B*0801, B*50, Cw*0602, Cw*0701
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, viral fitness and reversion, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 54336

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name B8-FL8(Nef)
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54804

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


Displaying record number 55499

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55657

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Alter2008 Galit Alter, Suzannah Rihn, Hendrik Streeck, Nickolas Teigen, Alicja Piechocka-Trocha, Kristin Moss, Kristen Cohen, Angela Meier, Florencia Pereyra, Bruce Walker, and Marcus Altfeld. Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8+ T Cells in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 82(19):9668-9677, Oct 2008. PubMed ID: 18579582. Show all entries for this paper.


Displaying record number 55848

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords HAART, ART

Notes

References

Rehr2008 Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick, Milo Huber, Urs Karrer, and Annette Oxenius. Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol., 82(7):3391-404, Apr 2008. PubMed ID: 18199637. Show all entries for this paper.


Displaying record number 1017

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97 IIIB)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, responses in children

Notes

References

Spiegel1999 H. M. Spiegel, E. DeFalcon, G. S. Ogg, M. Larsson, T. J. Beadle, P. Tao, A. J. McMichael, N. Bhardwaj, C. O'Callaghan, W. I. Cox, K. Krasinski, H. Pollack, W. Borkowsky, and D. F. Nixon. Changes in Frequency of HIV-1-Specific Cytotoxic T Cell Precursors and Circulating Effectors after Combination Antiretroviral Therapy in Children. J. Infect. Dis., 180:359-368, 1999. PubMed ID: 10395850. Show all entries for this paper.


Displaying record number 57689

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords memory cells

Notes

References

Meyer-Olson2010 Dirk Meyer-Olson, Brenna C. Simons, Joseph A. Conrad, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Coley B. Duncan, Ramesh Ramalingam, and Spyros A. Kalams. Clonal Expansion and TCR-Independent Differentiation Shape the HIV-Specific CD8+ Effector-Memory T-Cell Repertoire In Vivo. Blood, 116(3):396-405, Jul 22 2010. PubMed ID: 20424187. Show all entries for this paper.


Displaying record number 57836

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 52135

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97 BRU)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 52312

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FLK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52364

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B60, B8, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 52365

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B65, B8, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 52438

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human, macaque(B8)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 52646

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B62, B8, Cw3, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 52966

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(87-95)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A3, B7, B8
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, memory cells

Notes

References

Gamberg2004 Jane Gamberg, Lisa Barrett, Ian Bowmer, Constance Howley, and Michael Grant. Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection. J. Clin. Immunol., 24(2):115-124, Mar 2004. PubMed ID: 15024178. Show all entries for this paper.


Displaying record number 57933

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.


Displaying record number 1020

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Dyer1999 W. B. Dyer, G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1. J. Virol., 73:436-443, 1999. PubMed ID: 9847349. Show all entries for this paper.


Displaying record number 1300

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef( SF2)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FL8
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1366

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(92-99)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Epitope Name FLK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Oxenius2001b A. Oxenius, H. F. Gunthard, B. Hirschel, S. Fidler, J. N. Weber, P. J. Easterbrook, J. I. Bell, R. E. Phillips, and D. A. Price. Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load. Eur. J. Immunol., 31(4):1115-21, Apr 2001. PubMed ID: 11298336. Show all entries for this paper.


Displaying record number 1375

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(92-99)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name FLK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, escape, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1409

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.


Displaying record number 1421

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(88-95)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1578

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(88-95 SF2)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1705

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 1825

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000b P. J. Goulder, Y. Tang, C. Brander, M. R. Betts, M. Altfeld, K. Annamalai, A. Trocha, S. He, E. S. Rosenberg, G. Ogg, C. A. O'Callaghan, S. A. Kalams, R. E. McKinney, Jr., K. Mayer, R. A. Koup, S. I. Pelton, S. K. Burchett, K. McIntosh, and B. D. Walker. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J. Exp. Med., 192(12):1819-32, 18 Dec 2000. URL: http://www.jem.org/cgi/content/full/192/12/1819. PubMed ID: 11120778. Show all entries for this paper.


Displaying record number 1019

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(88-95)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.


Displaying record number 1014

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 54684

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(90-97)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A1, B7, B8
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 59394

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-20: A*02, B*08, B*49, Cw*07
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 55095

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


Displaying record number 54939

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A1, A10 (26); B17 (57), B8
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 60507

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Epitope Name B8-FL8
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA ACS 19957: A*01, A*02, B*0801, B*15; ACS 19885: A*01, A*02, B*0801, B*27; ACS 19861: A*01, A*02, B*0801, B*51; ACS 19453: A*01, A*02, B*0801, B*38; ACS 19342: A*01, A*02, B*0801, B*40; ACS 18840: A*02, B*0801, B*27; ACS 18839: A*0207, B*0801, B*27; ACS 18785: A*01, A*02, B*07, B*0801
Country Netherlands
Experimental methods Other, Tetramer binding
Keywords TCR usage

Notes

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 54913

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location  
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0101; B*0801, B*1401
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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