HIV molecular immunology database
Found 89 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Tetramer binding | |
Keywords |
Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | BRU | |
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(A2, B8) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | dendritic cells |
Ostrowski2000 M. A. Ostrowski, S. J. Justement, L. Ehler, S. B. Mizell, S. Lui, J. Mican, B. D. Walker, E. K. Thomas, R. Seder, and A. S. Fauci. The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses. J. Immunol., 165(11):6133-41, 1 Dec 2000. URL: http://www.jimmunol.org/cgi/content/full/165/11/6133. PubMed ID: 11086046. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-97 LAI) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, B7, B8, C*07:01, C*07:02 | |
Experimental methods | Chromium-release assay, HLA binding | |
Keywords | review, escape |
Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.
Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B*08-FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Other, Tetramer binding | |
Keywords |
Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | A, B, C, CRF01_AE, D, F, G, H | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization | |
Keywords | subtype comparisons, epitope processing |
Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B8-FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | ||
Keywords | review, rate of progression, acute/early infection |
Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding | |
Keywords | variant cross-reactivity, characterizing CD8+ T cells |
Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay, Cytotoxicity assay, Other | |
Keywords | epitope processing, escape |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | Nef-FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Tetramer binding | |
Keywords |
Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | (B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM13: A*01, A*01, B*08, B*57, C*06, C*07 | |
Country | United Kingdom | |
Experimental methods | Tetramer binding | |
Keywords | acute/early infection, optimal epitope |
Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.
Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | escape, HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A2, B49, B8, Cw7 | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition |
Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-96) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | rate of progression, acute/early infection, memory cells |
Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( SF2) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding | |
Keywords | TCR usage |
Meyer-Olson2006 Dirk Meyer-Olson, Kristen W. Brady, Melissa T. Bartman, Kristin M. O'Sullivan, Brenna C. Simons, Joseph A. Conrad, Coley B. Duncan, Shelly Lorey, Atif Siddique, Rika Draenert, Marylyn Addo, Marcus Altfeld, Eric Rosenberg, Todd M. Allen, Bruce D. Walker, and Spyros A. Kalams. Fluctuations of Functionally Distinct CD8+ T-Cell Clonotypes Demonstrate Flexibility of the HIV-Specific TCR Repertoire. Blood, 107(6):2373-2383, 15 Mar 2006. PubMed ID: 16322475. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | characterizing CD8+ T cells |
Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B*08-FL8 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | computer prediction | |
Country | Argentina | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | binding affinity, structure, assay or method development, contact residues |
Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B08-FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, escape |
Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, immunodominance, TCR usage, variant cross-reactivity |
Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 71101: A*01:01, A*03:01, B*08:01, B*35:03, C*04:01, C*07:01; 44149: A*01:01, A*24:02, B*07:01, B*08:01, C*07:01, C*07:02; 67200: A*01:01, A*24:02, B*08:01, B*57:01, C*06:02, C*07:01; 32645: A*01:01, A*02:01, B*08:01, B*35:03, C*04:01, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-97 LAI) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A*24:02, B*08:01, B*57:01, C*06:02, C*07:01; A*01:01, A*02:01, B*08:01, B*57:01, C*06:02, C*07:01; A2, A*24:02, B*08:01, B15, C*12, Cw7; A*01:01, A*02:01, B*08:01, B*57:01, C*06:02, C*07:01 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | rate of progression, escape, TCR usage, characterizing CD8+ T cells |
Dong2004 Tao Dong, Guillaume Stewart-Jones, Nan Chen, Philippa Easterbrook, Xiaoning Xu, Laura Papagno, Victor Appay, Michael Weekes, Chris Conlon, Celsa Spina, Susan Little, Gavin Screaton, Anton van der Merwe, Douglas D. Richman, Andrew J. McMichael, E. Yvonne Jones, and Sarah L. Rowland-Jones. HIV-Specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor. J. Exp. Med., 200(12):1547-1557, 20 Dec 2004. PubMed ID: 15596521. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, B*08:01 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | escape, acute/early infection |
Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | C | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | rate of progression |
Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Tetramer binding | |
Keywords | binding affinity |
Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FLK | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells |
Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords |
Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97 DU422) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding | |
Keywords | dendritic cells |
Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | B8-FL8 wt | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | in vitro stimulation or selection, peptide-HLA interaction | |
Country | United States | |
Experimental methods | Other | |
Keywords | binding affinity, escape |
Yang2010 Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, and Xu G. Yu. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS One, 5(12):e15084, 2010. PubMed ID: 21170342. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Subtype | A, B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, HLA associated polymorphism |
Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding | |
Keywords | characterizing CD8+ T cells |
Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | nef 90-97 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | France | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other | |
Keywords | binding affinity, elite controllers |
Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B*08-FL8 | |
Subtype | C | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | elite controllers |
Koofhethile2016 Catherine K. Koofhethile, Zaza M. Ndhlovu, Christina Thobakgale-Tshabalala, Julia G. Prado, Nasreen Ismail, Zenele Mncube, Lungile Mkhize, Mary van der Stok, Nonhlanhla Yende, Bruce D. Walker, Philip J. R. Goulder, and Thumbi Ndung'u. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J. Virol., 90(15):6818-6831, 1 Aug 2016. PubMed ID: 27194762. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | assay or method development, NK cells |
Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*35:01, B*35:08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | dynamics, characterizing CD8+ T cells, chronic infection |
Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | TCR usage, characterizing CD8+ T cells |
Alter2008 Galit Alter, Suzannah Rihn, Hendrik Streeck, Nickolas Teigen, Alicja Piechocka-Trocha, Kristin Moss, Kristen Cohen, Angela Meier, Florencia Pereyra, Bruce Walker, and Marcus Altfeld. Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8+ T Cells in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 82(19):9668-9677, Oct 2008. PubMed ID: 18579582. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B62, B8, Cw3, Cw7 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, acute/early infection, early-expressed proteins |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | Switzerland | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | HAART, ART |
Rehr2008 Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick, Milo Huber, Urs Karrer, and Annette Oxenius. Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol., 82(7):3391-404, Apr 2008. PubMed ID: 18199637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | A, B, C, D | |
Species (MHC/HLA) | human, macaque(B8) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B65, B8, Bw6 | |
Experimental methods | ||
Keywords | HAART, ART |
Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|
Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.
Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B60, B8, Bw6 | |
Experimental methods | ||
Keywords | HAART, ART |
Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FLK | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | Germany, United States | |
Experimental methods | Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | memory cells |
Meyer-Olson2010 Dirk Meyer-Olson, Brenna C. Simons, Joseph A. Conrad, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Coley B. Duncan, Ramesh Ramalingam, and Spyros A. Kalams. Clonal Expansion and TCR-Independent Differentiation Shape the HIV-Specific CD8+ Effector-Memory T-Cell Repertoire In Vivo. Blood, 116(3):396-405, Jul 22 2010. PubMed ID: 20424187. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97 IIIB) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, responses in children |
Spiegel1999 H. M. Spiegel, E. DeFalcon, G. S. Ogg, M. Larsson, T. J. Beadle, P. Tao, A. J. McMichael, N. Bhardwaj, C. O'Callaghan, W. I. Cox, K. Krasinski, H. Pollack, W. Borkowsky, and D. F. Nixon. Changes in Frequency of HIV-1-Specific Cytotoxic T Cell Precursors and Circulating Effectors after Combination Antiretroviral Therapy in Children. J. Infect. Dis., 180:359-368, 1999. PubMed ID: 10395850. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97 BRU) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, A*03:01, B*08:01, B*35:03, C*04:01, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder2000b P. J. Goulder, Y. Tang, C. Brander, M. R. Betts, M. Altfeld, K. Annamalai, A. Trocha, S. He, E. S. Rosenberg, G. Ogg, C. A. O'Callaghan, S. A. Kalams, R. E. McKinney, Jr., K. Mayer, R. A. Koup, S. I. Pelton, S. K. Burchett, K. McIntosh, and B. D. Walker. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J. Exp. Med., 192(12):1819-32, 18 Dec 2000. URL: http://www.jem.org/cgi/content/full/192/12/1819. PubMed ID: 11120778. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(88-95 SF2) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(88-95) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-99) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FLK | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI), immunodominance, escape, acute/early infection |
Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | (B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, review, escape, characterizing CD8+ T cells |
daSilva2003 Jack da Silva. The Evolutionary Adaptation of HIV-1 to Specific Immunity. Curr. HIV Res., 1(3):363-371, Jul 2003. PubMed ID: 15046259. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(87-95) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A28, A3, B7, B8 | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, memory cells |
Gamberg2004 Jane Gamberg, Lisa Barrett, Ian Bowmer, Constance Howley, and Michael Grant. Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection. J. Clin. Immunol., 24(2):115-124, Mar 2004. PubMed ID: 15024178. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97 B consensus) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | vaccine | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | dynamics, escape, mutation acquisition |
Vaccine type | adeno-associated virus (AAV) |
---|---|
Vaccine component | gp120 |
Brainard2004 Diana M. Brainard, William G. Tharp, Elva Granado, Nicholas Miller, Alicja K. Trocha, Xiang-Hui Ren, Brian Conrad, Ernest F. Terwilliger, Richard Wyatt, Bruce D. Walker, and Mark C. Poznansky. Migration of Antigen-Specific T Cells away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol., 78(10):5184-5193, May 2004. PubMed ID: 15113900. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( SF2) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97 HXB2) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1365: A*01:01, A*02:01, B*08:01, B*50, C*06:02, C*07:01 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition, viral fitness and reversion, optimal epitope |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | B8-FL8(Nef) | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Dyer1999 W. B. Dyer, G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1. J. Virol., 73:436-443, 1999. PubMed ID: 9847349. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | (B8) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, vaccine antigen design |
Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(88-95) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-99) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FLK | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Oxenius2001b A. Oxenius, H. F. Gunthard, B. Hirschel, S. Fidler, J. N. Weber, P. J. Easterbrook, J. I. Bell, R. E. Phillips, and D. A. Price. Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load. Eur. J. Immunol., 31(4):1115-21, Apr 2001. PubMed ID: 11298336. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding | |
Keywords | immunodominance, acute/early infection, characterizing CD8+ T cells |
Lichterfeld2004 Mathias Lichterfeld, Daniel E. Kaufmann, Xu G. Yu, Stanley K. Mui, Marylyn M. Addo, Mary N. Johnston, Daniel Cohen, Gregory K. Robbins, Eunice Pae, Galit Alter, Alysse Wurcel, David Stone, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-Induced HIV-1-Specific CD4+ T Cells. J. Exp. Med., 200(6):701-12, Sep 20 2004. PubMed ID: 15381726. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B62, B8, Cw10, Cw7; A11, A29, B44, B8, Cw4, Cw7; A25, A32, B14, B8, Cw7, Cw8; A1, A3, B14, B8, Cw7, Cw8 | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, T-cell Elispot, Tetramer binding | |
Keywords | rate of progression, acute/early infection, characterizing CD8+ T cells |
Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | HAART, ART, memory cells, characterizing CD8+ T cells |
Daniel2004 Nathalie Daniel, Bénédicte Charmeteau, Sophie Grabar, Gilles Pialoux, Dominique Salmon, Nelly Bonilla, Marion Dupuis, Christelle Troadec, Willy Rozenbaum, Hanne Gahéry-Ségard, Jean-Gérard Guillet, and Muriel Andrieu. Use of Well-Defined HIV-Derived Epitopes to Evaluate CD4+ and CD8+ T Cell Responses in Patients with Chronic HIV-1 Infection Treated with HAART. AIDS Res. Hum. Retroviruses, 20(8):827-835, Aug 2004. PubMed ID: 15320987. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Epitope Name | FL8 | |
Species (MHC/HLA) | (B8) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion |
Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | binding affinity, acute/early infection |
Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(90-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, B7, B8 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | HAART, ART, escape, viral fitness and reversion |
Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | B8-FL8 | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | ACS 19957: A*01, A*02, B*08:01, B*15; ACS 19885: A*01, A*02, B*08:01, B*27; ACS 19861: A*01, A*02, B*08:01, B*51; ACS 19453: A*01, A*02, B*08:01, B*38; ACS 19342: A*01, A*02, B*08:01, B*40; ACS 18840: A*02, B*08:01, B*27; ACS 18839: A*02:07, B*08:01, B*27; ACS 18785: A*01, A*02, B*07, B*08:01 | |
Country | Netherlands | |
Experimental methods | Other, Tetramer binding | |
Keywords | TCR usage |
Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(89-97) | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | LTNP/EC-20: A*02, B*08, B*49, C*07 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(90-97) DNA(9064..9087) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FLKEKGGL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 014A-006: A*01:01, B*08:01, B*14:01, C*07:02, C*08:02; 402I15: A1, A10, B17, B8 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.