HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 58996

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Subtype A
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P17: A*02:01, A*68:01, B*50:01, B*58:01
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 60940

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location p2p7p1p6(70-77)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Patient MHC/HLA 63794: A*02:01:01G, B*07:02:01G, B*44:02:01G, C*07:04:01G; 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 57143

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords immunodominance, dendritic cells

Vaccine Details

Vaccine type polyepitope
Vaccine strain multiple epitope immunogen
Vaccine component Env, Gag, Pol, Vif, Vpu

Notes

References

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.


Displaying record number 62157

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-440)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name FS8
Subtype A1, D
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Country Uganda
Experimental methods HLA binding, Relative replication capacity assay
Keywords subtype comparisons, escape, HLA associated polymorphism

Notes

References

Kinloch2019 Natalie N. Kinloch, Guinevere Q. Lee, Jonathan M. Carlson, Steven W. Jin, Chanson J. Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B. Bwana, Kyle D. Cobarrubias, Peter W. Hunt, Jeff N. Martin, Mary Carrington, David R. Bangsberg, P. Richard Harrigan, Mark A. Brockman, and Zabrina L. Brumme. Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30305354. Show all entries for this paper.


Displaying record number 61991

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-439)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 57136

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Country Denmark
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type peptide
Vaccine strain multiple epitope immunogen
Vaccine component HIV-1, other

Notes

References

Kloverpris2009a Henrik Kloverpris, Ingrid Karlsson, Jesper Bonde, Mette Thorn, Lasse Vinner, Anders E. Pedersen, Julie L. Hentze, Betina S. Andresen, Inge M. Svane, Jan Gerstoft, Gitte Kronborg, and Anders Fomsgaard. Induction of Novel CD8+ T-Cell Responses during Chronic Untreated HIV-1 Infection by Immunization with Subdominant Cytotoxic T-Lymphocyte Epitopes. AIDS, 23(11):1329-1340, 17 Jul 2009. PubMed ID: 19528789. Show all entries for this paper.


Displaying record number 61794

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location  
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name FS8
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 58408

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 54531

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location p15(70-77)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 55372

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location  
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Show epitope variants
Epitope Name Gag 433
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords variant cross-reactivity

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 56061

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 57507

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location  
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods T-cell Elispot
Keywords vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine component Env, Gag, Nef, Pol, Vif, Vpu
Adjuvant CAF01

Notes

References

Fomsgaard2011 Anders Fomsgaard, Ingrid Karlsson, Gregers Gram, Christian Schou, Sheila Tang, Peter Bang, Ingrid Kromann, Peter Andersen, and Lars Vibe Andreasen. Development and Preclinical Safety Evaluation of a New Therapeutic HIV-1 Vaccine Based on 18 T-Cell Minimal Epitope Peptides Applying a Novel Cationic Adjuvant CAF01. Vaccine, 29(40):7067-7074, Sep 16 2011. PubMed ID: 21767590. Show all entries for this paper.


Displaying record number 52669

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HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name Gag433
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component Gag
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 61948

Download this epitope record as JSON.

HXB2 Location Gag(433-440)
p2p7p1p6(70-77)
DNA(2086..2109)
Gag Epitope Map
Author Location Gag(433-)
Epitope FLGKIWPS Epitope Alignment
FLGKIWPS epitope logo
Epitope Name FS8
Subtype A3, B, C, CRF02_AG
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design, non-susceptible form

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


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