HIV molecular immunology database
Found 15 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | LTNP/EC-21: A*01, A*02, B*15, B*81, C*08, C*18 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10(Integrase) | |
Subtype | B | |
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(185-194) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | HLA associated polymorphism |
Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, rate of progression, immunodominance |
Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion, HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(185-194) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(900-909) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10 | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(900-909) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10-Int | |
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding | |
Keywords | TCR usage, characterizing CD8+ T cells |
Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(185-194) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10 | |
Subtype | B | |
Species (MHC/HLA) | (B*27) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(900-909) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10 | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(185-194) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10 | |
Subtype | A1, B, C | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus |
---|---|
Vaccine strain | B clade HXB2, A clade 92RW020, C clade 97ZA012 |
Vaccine component | Env, Gag-Pol |
Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(900-909) Integrase(185-194) DNA(4782..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(900-909) | |
Epitope |
FKRKGGIGGY
|
Epitope Alignment
|
Epitope Name | FY10 | |
Species (MHC/HLA) | human(C*01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.