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Displaying record number 856

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HXB2 Location	gp160(685-693) gp41(174-182) DNA(8277..8303)	gp160 Epitope Map
Author Location	Env(686-694 subtype B)
Epitope	`FIMIVGGLV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	vaccine
Experimental methods
Keywords	binding affinity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade MN
Vaccine component	gp160

Notes

Ten HIV-1+ HLA A2 asymptomatic individuals were given two courses of HIV-1 MN rgp160 vaccine over a 2 year period.
Two hundred and fifty three HIV-1 peptides of 9 or 10 aa possessing the HLA-A2.1 binding motif (Leu at position 2, Val at the C terminus) were identified in gp160, of which 25 had a high or intermediate binding affinity.
Eleven peptides were studied that had high HLA-A2 binding affinity -- a CTL response was detected to 9/11 peptides in at least 1 individual.
CTL responses after reimmunization may include recall responses -- only individuals with vaccine cross-reactive sequences prior to vaccination showed detectable CTL responses.
ALTERNATIVE EPITOPE: IMIVGGLVGL -- no CTL response was shown to the peptides FIMIVGGLV or IMIVGGLVGL.

References

Kundu1998a S. K. Kundu, M. Dupuis, A. Sette, E. Celis, F. Dorner, M. Eibl, and T. C. Merigan. Role of preimmunization virus sequences in cellular immunity in HIV- infected patients during HIV type 1 MN recombinant gp160 immunization. AIDS Res. Hum. Retroviruses, 14:1669-78, 1998. PubMed ID: 9870321. Show all entries for this paper.