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Displaying record number 53855

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HXB2 Location	Pol(647-656) RT(492-501) DNA(4023..4052)	Pol Epitope Map
Author Location	Pol(647-656)
Epitope	EVNIVTDSQY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords	immunodominance, optimal epitope

Notes

• Reverse immunogenetics was used to identify HIV-1 epitopes presented by HLA-A*2601. 110 peptides were predicted to bind to HLA-A*2601. 24 of these were demonstrated to bind through a HLA-A*2601 stabilization assay. Four of these, including this one, were shown to be epitopes endogenously presented by this allele, that can induce peptide-specific CD8 T-cells. HLA-A*2601 is common in Asia.
• This epitope was recognized in only 1/7 HLA-A*2601 HIV infected individuals.

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.