Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 60607

Download this epitope record as JSON.

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	p24(35-43)
Epitope	EVIPMFTAL	Epitope Alignment
		Show epitope variants
Subtype	B, C
Species (MHC/HLA)	human(A*26, A*26:01, A*26:02, A*26:03, C*01, C*01:02)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Subtype-specific substitutions in two HIV Gag regions (fragments F1, amino acids (aa) 5-46, and F2 aa 100-143) result in novel adaptations that affect epitope processing efficiency. Consequent low epitope abundance is associated with weak T cell response and greater immune escape and therefore with disease state. Conversely, epitopes from these regions when restricted by certain rare HLA I alleles, are associated with greater production and resulting CTL response, therefore delayed disease progression.
• Most epitopes were found to be processed as precursors with N-terminal extensions beyond the optimal epitope. Only 4 epitopes in this region were associated with delayed progression - HLA-B*5701/03-restricted IW9 (ISPRTLNAW), KF11 (KAFSPEVIPMF), TW10 (TSTLQEQIGW) and HLA-B*2705-restricted KK10 (KRWIILGLNK).
• Regardless of ethnic group, white or African, a significant three-way interaction was found between HLA allelic frequency, epitope yield and ethnicity for epitopes of N-terminal fragment F1 (NF1) and C-terminal as well as middle F2 (CF2 and MF2). C-terminal F1 (CF1) epitope yields however, showed a significant difference between ethnic groups. Also, for identical HLA-mediated selection pressure in both Africans and whites, HIV-C had a lower concentration than HIV-B, especially at lower HLA allelic frequencies.
• Epitope EVIPMFTAL, EL-9, is from fragment F1, and restricted by HLA-A*26,A*2601,A*2602,A*2603, Cw*01,Cw*0102. For subtype C, the natural processed form was AWVKVVEEKAFSPEVIPMFTAL.

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.

Displaying record number 53965

Download this epitope record as JSON.

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	( C consensus)
Epitope	EVIPMFTAL	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, optimal epitope

Notes

• A comprehensive analysis of 160 class I T cell responses in 578 individuals from KwaZulu-Natal, South Africa was performed. Gag-specific responses were associated with lowering viremia, while Env, accessory and regulatory protein-specific responses were associated with higher viremia.
• EVIPMFTAL is an optimal epitope.

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.

Displaying record number 55675

Download this epitope record as JSON.

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	Gag
Epitope	EVIPMFTAL	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(A*26:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

• Transmission of HIV-1-escape variants from individuals with protective HLA-B*57/-B*5801 alleles to those without these alleles was studied to determine if infection with such replication-deficient mutants offered any advantage to the new host. Dependency between slower rate of disease progression in the newly infected subject and protective genotype of the infecting individual was suggested.
• HLA-A*2601-restricted epitope EVIPMFTAL, within peptide AFSPEVIPMFTALSEGA was able to elicit CTL response in a T242N/A146X viral-mutation-carrying subject.

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.

Displaying record number 57751

Download this epitope record as JSON.

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	p24
Epitope	EVIPMFTAL	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(A*26:38)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*23:01, A*26:38, B*44:03, B*51:01, C*03:03, C*07:01
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, acute/early infection

Notes

• Immunological responses in early subtype C infection were characterized. Nef, Pol and Gag were the most frequently targeted proteins from as early as 3 to 8 weeks postinfection. Nef was immunodominant, with more than 75% of individuals recognizing Nef. Many responses to peptide pools were derived from the recognition of one immunodominant peptide.
• One A*2638-positive acutely HIV-1-infected individual had a peptide response to presumed optimal epitope EVIPMFTAL within peptide AFSPEVIPMFTALSEGA. There was no viral escape.

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.