HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 59654

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(167-175)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(A*25)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 170

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24(167-175)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 52934

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection
Patient MHC/HLA A26, B27
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, rate of progression, immunodominance, escape

Notes

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.


Displaying record number 55935

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name EL9(p24)
Subtype B
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54267

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name A26-EL9(p24)
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54874

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location  
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Species (MHC/HLA) human(A26)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 59655

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(167-175)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(A*26)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58553

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name A26-EL9
Subtype B
Species (MHC/HLA) human(A*26)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 60606

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24(35-43)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Show epitope variants
Epitope Name EL-9
Subtype B
Species (MHC/HLA) human(A*26, A*2601, A*2602, A*2603, Cw*01, Cw*0102)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 169

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24(167-175 LAI)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*2601)
Immunogen  
Experimental methods  
Keywords subtype comparisons

Notes

References

Goulder1996b P. Goulder, C. Conlon, K. McIntyre, and A. McMichael. Identification of a Novel Human Leukogen Antigen A26-Restricted Epitope in a Conserved Region of Gag. AIDS, 10(12):1441-1443, 1996. This paper is correspondence briefly describing the identification and characterization of an immunodominant A26-CTL epitope in an asymptomatic HIV+ individual. PubMed ID: 8902082. Show all entries for this paper.


Displaying record number 53856

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(169-177)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Subtype B
Species (MHC/HLA) human(A*2601)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding, Other
Keywords subtype comparisons, immunodominance, optimal epitope

Notes

References

Satoh2005 Manami Satoh, Yuji Takamiya, Shinichi Oka, Katsushi Tokunaga, and Masafumi Takiguchi. Identification and Characterization of HIV-1-Specific CD8+ T Cell Epitopes Presented by HLA-A*2601. Vaccine, 23(29):3783-3790, 31 May 2005. PubMed ID: 15893615. Show all entries for this paper.


Displaying record number 55523

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(169-177 SF2)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Subtype B
Species (MHC/HLA) human(A*2601, A*2602, A*2603)
Immunogen HIV-1 infection
Country Japan
Experimental methods HLA binding, Intracellular cytokine staining
Keywords binding affinity, immunodominance

Notes

References

Kawashima2008 Yuka Kawashima, Manami Satoh, Shinichi Oka, Takuma Shirasaka, and Masafumi Takiguchi. Different Immunodominance of HIV-1-Specific CTL Epitopes among Three Subtypes of HLA-A*26 Associated with Slow Progression to AIDS. Biochem. Biophys. Res. Commun., 366(3):612-616, 15 Feb 2008. PubMed ID: 18035044. Show all entries for this paper.


Displaying record number 58612

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(169-177 SF2)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Subtype B
Species (MHC/HLA) human(A*2601, A*2602, A*2603)
Immunogen HIV-1 infection
Country Japan
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53745

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(169-177 SF2)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Show epitope variants
Subtype A, B, C, CRF01_AE, D
Species (MHC/HLA) human(A*2601, A*2603)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding
Keywords binding affinity, subtype comparisons, rate of progression, immunodominance, escape, HLA cross-presentation, variant cross-reactivity

Notes

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.


Displaying record number 59656

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag(167-175)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56309

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location p24(167-175 SF2, HXBc2/Bal R5)
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Subtype B
Species (MHC/HLA) human(Cw3)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A2, B40, B57, Cw3, Cw6
Country United States
Experimental methods Cytokine production, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay
Keywords supervised treatment interruptions (STI), immunodominance, characterizing CD8+ T cells, drug resistance

Notes

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 58033

HXB2 Location Gag(167-175)
p24(35-43)
DNA(1288..1314)
Gag Epitope Map
Author Location Gag
Epitope EVIPMFSAL Epitope Alignment
EVIPMFSAL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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