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Displaying record number 62234

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HXB2 Location	Vif(54-63) DNA(5200..5229)	Vif Epitope Map
Author Location	Vif(54-63)
Epitope	EVHIPLGDAR	Epitope Alignment
		Show epitope variants
Epitope Name	Vif-ER10
Subtype	C
Species (MHC/HLA)	human(A*68:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	133-C: A*68:01, A*74:01, B*58:02, B*81:01, C*04:01, C*06:02; 133-M: A*03:01, A*68:01, B*42:01, B*58:02, C*06:02, C*12:04
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	dynamics, responses in children, mother-to-infant transmission, rate of progression, escape

Notes

• 11 perinatally infected pediatric slow progressors (PSPs) were followed longitudinally for a decade from birth to examine CTL responses to circulating and autologous HIV. It was found by ultra-deep sequencing that though, like adults, children develop variants early in infection; unlike adults, pediatric anti-variant CTL are generated.
• EliSpot was used to determine that non-Gag/Pol-specific responses (i.e. Env or Nef responses) are higher within the first weeks of infection for pediatric viremic non-controllers (VNCs) just as seen previously in adult VNCs and vice versa in pediatric VCs (PSPs). Therefore non-Gag/Pol-specific CTL responses are confirmed to be linked to higher VL and progression to disease.
• In pediatric A*6801⁺ VC, 133-C, A*6801-restricted ER10 was transmitted, likely with some mutations, from the A*6801⁺ mother (Patient Rec. #4449).

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.