HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 52200

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.


Displaying record number 60937

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp160(584-592)
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Patient MHC/HLA 94153: A*25:01, A*68:01, B*14:02, B*44:02, C*05:01, C*08:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 1677

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(589-597)
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 56649

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Show epitope variants
Species (MHC/HLA) human(B*14:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*01:01, A*23:01, B*14:02, B*57:01, C*07:01, C*08:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords escape, acute/early infection

Notes

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


Displaying record number 58235

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*14:02)
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*01:01, A*23:01, B*14:02, B*57, C*07:01, C*08:02
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords dynamics, escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 53808

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp160
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*02:02, A*74:01, B*15:03, B*58:02, C*02:02, C*06:02; A*02:01, A*30:09, B*45:01, B*58:02, C*02:02, C*16:01
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity

Vaccine Details

Vaccine type vaccinia
Vaccine strain A clade, B clade, D clade NDK, C clade consensus
Vaccine component Env

Notes

References

McKinnon2005 Lyle R. McKinnon, T. Blake Ball, Joshua Kimani, Charles Wachihi, Lucy Matu, Ma Luo, Joanne Embree, Keith R. Fowke, and Francis A. Plummer. Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade. J. Acquir. Immune Defic. Syndr., 40(3):245-249, 1 Nov 2005. PubMed ID: 16249696. Show all entries for this paper.


Displaying record number 61062

Download this epitope record as JSON.

HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(73-81)
Epitope ERYLRDQQL Epitope Alignment
ERYLRDQQL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*01:01, A*23:01, B*14:02, B*57, C*07:01, C*08:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


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