HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 56 matching records:

Displaying record number 59630

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59629

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54520

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Subtype A
Species (MHC/HLA) human(A*32, B*14)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation
Keywords assay or method development

Notes

References

McKinnon2007 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Paul J. McLaren, Jillian L. M. Waruk, Xiaojuan Mao, Sue Ramdahin, A. Omu Anzala, Jane Kamene, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Epitope Cross-Reactivity Frequently Differs between Central and Effector Memory HIV-Specific CD8+ T Cells. J. Immunol., 178(6):3750-3756, 15 Mar 2007. PubMed ID: 17339473. Show all entries for this paper.


Displaying record number 1506

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592 HXB2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name E4
Subtype B
Species (MHC/HLA) human(A*32, B*14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 55958

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9(gp41)
Subtype B
Species (MHC/HLA) human(A32)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 55142

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Species (MHC/HLA) human(A32, B14)
Immunogen  
Experimental methods  
Keywords subtype comparisons, viral fitness and reversion

Notes

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.


Displaying record number 57087

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(73-81 DU422)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B*08:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 59628

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58552

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name B14-EL9
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 55154

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B*14)
Immunogen in vitro stimulation or selection, HIV-1 infection
Experimental methods Other
Keywords kinetics

Notes

References

Wick2005 W. David Wick, Otto O. Yang, Lawrence Corey, and Steven G. Self. How Many Human Immunodeficiency Virus Type 1-Infected Target Cells Can a Cytotoxic T-Lymphocyte Kill? J. Virol., 79(21):13579-13586, Nov 2005. PubMed ID: 16227278. Show all entries for this paper.


Displaying record number 62252

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(589-597 HXB2, HIV-1 IIIB, HIV-1 MN, HIV-1 RF)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Patient MHC/HLA 15160: A*03, A*32, B*14, B*44
Country United States
Experimental methods Chromium-release assay
Keywords autologous responses, optimal epitope

Notes

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.


Displaying record number 53331

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location ( C consensus)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype C
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 829

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 831

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kalams1996 S. A. Kalams, R. P. Johnson, M. J. Dynan, K. E. Hartman, T. Harrer, E. Harrer, A. K. Trocha, W. A. Blattner, S. P Buchbinder, and B. D. Walker. T Cell Receptor Usage and Fine Specificity of Human Immunodeficiency Virus Type 1 Specific Cytotoxic T Lymphocyte Clones: Analysis of Quasispecies Recognition Reveals a Dominant Response Directed against a Minor In Vivo Variant. J. Exp. Med., 183:1699-1679, 1996. PubMed ID: 8666925. Show all entries for this paper.


Displaying record number 832

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp120(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 1289

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41( SF2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1490

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name 588K
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, TCR usage

Notes

References

Islam2001 S. A. Islam, C. M. Hay, K. E. Hartman, S. He, A. K. Shea, A. K. Trocha, M. J. Dynan, N. Reshamwala, S. P. Buchbinder, N. O. Basgoz, and S. A. Kalams. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J. Virol., 75(10):4907-11, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/10/4907. PubMed ID: 11312363. Show all entries for this paper.


Displaying record number 1526

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(589-597 SF2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1758

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41( JRCSF)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Severino2000 M. E. Severino, N. V. Sipsas, P. T. Nguyen, S. A. Kalams, B. D. Walker, R. P. Johnson, and O. O. Yang. Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes. J. Virol., 74(14):6695-9, Jul 2000. URL: http://jvi.asm.org/cgi/content/full/74/14/6695. PubMed ID: 10864688. Show all entries for this paper.


Displaying record number 1846

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41( SF2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 52205

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(589-597)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins, kinetics

Notes

References

Guillon2002a Christophe Guillon, Carel A. van Baalen, Patrick H. M. Boers, Esther J. Verschuren, Rob A. Gruters, and Albert D. M. E. Osterhaus. Construction and Characterisation of Infectious Recombinant HIV-1 Clones Containing CTL Epitopes from Structural Proteins in Nef. J Virol Methods, 99(1-2):115-121, Jan 2002. PubMed ID: 11684309. Show all entries for this paper.


Displaying record number 52238

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef

Notes

References

Yang2002 Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong, Richard Wyatt, and Joseph Sodroski. Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin. J. Virol., 76(9):4634-4642, 1 May 2002. PubMed ID: 11932429. Show all entries for this paper.


Displaying record number 52269

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name B14-EL9(gp41)
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A32, B14, B7
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 52430

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 53153

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(73-81)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name Env EL9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords binding affinity, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 53367

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location ( B consensus)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A29, B14, B44, Cw8; A25, A32, B14, B8, Cw7, Cw8
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53761

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Epitope Name EL9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*68, B*14, B*52, C*08, C*12
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, characterizing CD8+ T cells, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53783

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Species (MHC/HLA) (B14)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 54343

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name B14-EL9(gp41)
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54886

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location  
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 815

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wagner1998b L. Wagner, O. O. Yang, E. A. Zepeda, Y. Ge, S. A. Kalams, B. D. Walker, M. S. Pasternack, and A. D. Luster. Beta-Chemokines Are Released from HIV-1-Specific Cytolytic T Cell Granules Complexed to Proteoglycans. Nature, 391:908-911, 1998. PubMed ID: 9495345. Show all entries for this paper.


Displaying record number 57943

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(73-81)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Epitope Name EL9
Subtype A1, B, C
Species (MHC/HLA) human(B14)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 58223

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp160( LAI)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords immunodominance

Notes

References

Shankar1996 P. Shankar, J. A. Fabry, D. M. Fong, and J. Lieberman. Three Regions of HIV-1 gp160 Contain Clusters of Immunodominant CTL Epitopes. Immunol. Lett., 52:23-30, 1996. PubMed ID: 8877415. Show all entries for this paper.


Displaying record number 57216

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) (B14)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 816

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Kalams1999b S. A. Kalams, P. J. Goulder, A. K. Shea, N. G. Jones, A. K. Trocha, G. S. Ogg, and B. D. Walker. Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy. J. Virol., 73:6721-6728, 1999. PubMed ID: 10400770. Show all entries for this paper.


Displaying record number 817

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(591-599 SF2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Lieberman1997 J. Lieberman, J. A. Fabry, D. M. Fong, and G. R. Parkerson 3rd. Recognition of a Small Number of Diverse Epitopes Dominates the Cytotoxic T Lymphocytes Response to HIV Type 1 in an Infected Individual. AIDS Res. Hum. Retroviruses, 13:383-392, 1997. PubMed ID: 9075479. Show all entries for this paper.


Displaying record number 818

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(591-599 SF2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 819

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 820

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 821

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Yang1996 O. O. Yang, S. A. Kalams, M. Rosenzweig, A. Trocha, N. Jones, M. Koziel, B. D. Walker, and R. P. Johnson. Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes. J. Virol., 70:5799-5806, 1996. PubMed ID: 8709196. Show all entries for this paper.


Displaying record number 822

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Yang1997 O. O. Yang, S. A. Kalams, A. Trocha, H. Cao, A. Luster, R. P. Johnson, and B. D. Walker. Suppression of Human Immunodeficiency Virus Type 1 Replication by CD8+ Cells: Evidence for HLA Class I-Restricted Triggering of Cytolytic and Noncytolytic Mechanisms. J. Virol., 71:3120-3128, 1997. Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both cytolytic and noncytolytic mechanisms. The predominant mechanism requires direct contact of CTL with the infected cells, is HLA class I restricted, and can achieve complete elimination of detectable virus in infected cell cultures. Inhibition occurs even at high multiplicities of infection or at ratios of CTL to CD4 cells as low as 1:1,000. The other mechanism is mediated by soluble inhibitory factors which are triggered in an antigen-specific and HLA-restricted fashion but then act without HLA restriction. PubMed ID: 9060675. Show all entries for this paper.


Displaying record number 824

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592 PV22)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Johnson1992 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Identification of Overlapping HLA Class I-Restricted Cytotoxic T Cell Epitopes in a Conserved Region of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Definition of Minimum Epitopes and Analysis of the Effects of Sequence Variation. J. Exp. Med., 175:961-971, 1992. Fine mapping and mutational analysis of gp41 epitopes: ERYLKDQQL, HLA B14 and YLKDQQLL, HLA B8. PubMed ID: 1372650. Show all entries for this paper.


Displaying record number 826

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592 PV22)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Jassoy1993 C. Jassoy, T. Harrer, T. Rosenthal, B. A. Navia, J. Worth, R. P. Johnson, and B. D. Walker. Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes Release gamma Interferon, Tumor Necrosis Factor alpha (TNF-alpha), and TNF-beta when They Encounter Their Target Antigens. J. Virol., 67:2844-2852, 1993. In this study the ability of HIV-1-specific CTL clones derived from seropositive persons to release gamma interferon (IFN-$\gamma$), tumor necrosis factor alpha (TNF-$\alpha$), and TNF-$\beta$ upon contact with target cells presenting viral antigen was assessed. Epitopes: p17: KIRLRPGGKKKYKLKHIVWASRELE, A3; gp41: VERYLKDQQL, B14 and A28, ERYLKDQQL, B14; RT: AIFQSSMTKILEPFRKQNPDIVIYQ, A11; and Nef SQRRQDILDLWIYHTQGYFPDWQNY, B13. PubMed ID: 7682629. Show all entries for this paper.


Displaying record number 827

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592 HXB2)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kalams1994 S.A. Kalams, R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. Longitudinal Analysis of T Cell Receptor (TCR) Gene Usage by HIV-1 Envelope-Specific Cytotoxic T-Lymphocyte Clones Reveals a Limited TCR Repertoire. J. Exp. Med., 179:1261-1271, 1994. This paper presents an in-depth longitudinal study of T-cell receptor gene usage to a well defined HLA B14 restricted gp41 epitope. Ten CTL clones were derived from a single individual over 31 months. T-cell receptor V-D-J sequencing was performed on PCR amplification products. All ten clones utilized V$\alpha$14 and V$\beta$4 genes; observed limited T-cell receptor diversity to an immunodominant epitope was suggested to facilitate immune escape. gp41 epitope: ERYLKDQQL. An HLA B14 restricted RT epitope from this individual used V$\alpha$21 and V$\beta$14, showing use of these genes was not a feature of all HLA B14 restricted clones from this individual. RT epitope: AIYLALQDSGLEVNIVTDSQYALGI. PubMed ID: 8145043. Show all entries for this paper.

Kalams1996 S. A. Kalams, R. P. Johnson, M. J. Dynan, K. E. Hartman, T. Harrer, E. Harrer, A. K. Trocha, W. A. Blattner, S. P Buchbinder, and B. D. Walker. T Cell Receptor Usage and Fine Specificity of Human Immunodeficiency Virus Type 1 Specific Cytotoxic T Lymphocyte Clones: Analysis of Quasispecies Recognition Reveals a Dominant Response Directed against a Minor In Vivo Variant. J. Exp. Med., 183:1699-1679, 1996. PubMed ID: 8666925. Show all entries for this paper.


Displaying record number 828

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B14)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

DiBrino1994b M. DiBrino, K. C. Parker, D. H. Margulies, J. Shiloach, R. V. Turner, M. Garfield, W. E. Biddison WE, and J. E. Coligan. The HLA-B14 Peptide Binding Site Can Accommodate Peptides with Different Combinations of Anchor Residues. J. Biol. Chem., 269(51):32426-32434, 1994. PubMed ID: 7528217. Show all entries for this paper.


Displaying record number 833

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41( subtype B)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*14:02, B14)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 55292

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*14:02, B14)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*35:01, B44, C*16, Cw7; A*02:01, A19, B14, B44, C*16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


Displaying record number 54065

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location ( C consensus)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype C
Species (MHC/HLA) human(B*14:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 825

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592 PV22)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human(B*14:02)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57554

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location  
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords acute/early infection, assay or method development

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 830

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Borrow1994 P. Borrow, H. Lewicki, B. H. Hahn, G. M. Shaw, and M. B. Oldstone. Virus-Specific CD8+ Cytotoxic T-Lymphocyte Activity Associated with Control of Viremia in Primary Human Immunodeficiency Virus Type 1 Infection. J. Virol., 68:6103-6110, 1994. PubMed ID: 8057491. Show all entries for this paper.


Displaying record number 56132

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*68:02, A*74:01, B*15:10, B*49:01, C*03:04, C*07:01; A*29:02, A*36:01, B*15:10, B*42:01, C*03:04, C*17:01
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation
Keywords assay or method development

Notes

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.


Displaying record number 53221

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp160(598-597 BORI, SUMA)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Show epitope variants
Epitope Name gp160 EL9
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*11:03, A*24:02, B*14:02, B*15:01, C*08:02; BORI: A02, A29, B14, B44; SUMA: A*11:03, A*24:02, B*14:02, B*15:01, C*08:02, C*12:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords dynamics, immunodominance, escape, acute/early infection, autologous responses, optimal epitope

Notes

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.


Displaying record number 823

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HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location gp41(584-592)
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Price1995 P. Price, R. P. Johnson, D. T. Scadden, C. Jassoy, T. Rosenthal, S. Kalams, and B. D. Walker. Cytotoxic CD8+ T Lymphocytes Reactive with Human Immunodeficiency Virus-1 Produce Granulocyte/Macrophage Colony-Stimulating Factor and Variable Amounts of Interleukins 2, 3, and 4 following Stimulation with the Cognate Epitope. Clin. Immunol. Immunopathol., 74:100-106, 1995. Cytokine release from stimulated CTL clones derived from either the peripheral blood or CSF of 3 patients was studied. HLA restriction was determined for two of seven clones. GM-CSF and TNF-$\alpha$ and IFN-$\gamma$ were produced by all clones; most clones produced low amounts of IL-2, IL-3, and IL-4. PubMed ID: 7527747. Show all entries for this paper.


Displaying record number 58265

Download this epitope record as JSON.

HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location Env
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.


Displaying record number 54912

Download this epitope record as JSON.

HXB2 Location gp160(584-592)
gp41(73-81)
DNA(7974..8000)
gp160 Epitope Map
Author Location  
Epitope ERYLKDQQL Epitope Alignment
ERYLKDQQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA 014A-006: A*01:01, B*08:01, B*14:01, C*07:02, C*08:02
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, acute/early infection

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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