Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 340

Download this epitope record as JSON.

HXB2 Location	Gag(307-318) p24(175-186) DNA(1708..1743)	Gag Epitope Map
Author Location	p24(307-318)
Epitope	EQASQEVKNWMT	Epitope Alignment
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• HIV is found in semen both as cell-associated and cell-free forms, and HIV-specific CTL could be found in the semen of 5/5 men with CD4 greater than 500 -- 3 of the men were analyzed in detail and had broad CTL to gag, env and pol.
• Two CTL lines from one donor recognized this epitope.
• Isolation of CTLs specific to HIV in both male and female urinal tracts provide evidence that virus-specific lymphocytes come from the urogenital mucosa, and the authors speculate that CTL in mucosal tissues may be correlated with lower viral load in semen and reduced transmission.

References

Quayle1998 A. J. Quayle, W. M. Coston, A. K. Trocha, S. A. Kalams, K. H. Mayer, and D. J. Anderson. Detection of HIV-1-Specific CTLs in the Semen of HIV-Infected Individuals. J. Immunol., 161:4406-4410, 1998. PubMed ID: 9780219. Show all entries for this paper.