HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 57075

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location p24(159-168 DU422)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 55882

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location Gag
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype B, D
Species (MHC/HLA) human(A*02:01, A2)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons

Notes

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.


Displaying record number 53146

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location  
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Epitope Name E10F
Species (MHC/HLA) mouse(H-2Ld)
Immunogen vaccine
Experimental methods Chromium-release assay, Cytokine production
Keywords epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA, virus-like particle (VLP), polyepitope
Vaccine component Gag, p24 Gag, Env V3

Notes

References

Wild2004 Jens Wild, Alexandra Bojak, Ludwig Deml, and Ralf Wagner. Influence of Polypeptide Size and Intracellular Sorting on the Induction of Epitope-Specific CTL Responses by DNA Vaccines in a Mouse Model. Vaccine, 22(13-14):1732-1743, 15 Apr 2004. PubMed ID: 15068857. Show all entries for this paper.


Displaying record number 59106

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location p24(159-168)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype B
Species (MHC/HLA) human, mouse(H-2d)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Tat

Notes

References

Reguzova2015 Alena Reguzova, Denis Antonets, Larisa Karpenko, Alexander Ilyichev, Rinat Maksyutov, and Sergei Bazhan. Design and Evaluation of Optimized Artificial HIV-1 Poly-T Cell-Epitope Immunogens. PLoS One, 10(3):e0116412, 2015. PubMed ID: 25786238. Show all entries for this paper.


Displaying record number 1582

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location Gag(291-300)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords Th1

Vaccine Details

Vaccine type DNA, DNA with protein boost
Vaccine strain B clade LAI
Vaccine component Gag, Nef, Tat
Adjuvant IL-18

Notes

References

BillautMulot2001 O. Billaut-Mulot, T. Idziorek, M. Loyens, A. Capron, and G. M. Bahr. Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost. Vaccine, 19(20-22):2803-11, 6 Apr 2001. PubMed ID: 11282190. Show all entries for this paper.


Displaying record number 52589

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location p24
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Epitope Name E10F
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods Chromium-release assay
Keywords  

Vaccine Details

Vaccine type DNA
Vaccine component Gag

Notes

References

Bojak2002a Alexandra Bojak, Jens Wild, Ludwig Deml, and Ralf Wagner. Impact of Codon Usage Modification on T Cell Immunogenicity and Longevity of HIV-1 Gag-Specific DNA Vaccines. Intervirology, 45(4-6):275-86, 2002. PubMed ID: 12566710. Show all entries for this paper.


Displaying record number 54967

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location Gag(291-300)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection, peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, T-cell crossreactivity to human proteins

Notes

References

Rolland2007a Morgane Rolland, David C. Nickle, Wenjie Deng, Nicole Frahm, Christian Brander, Gerald H. Learn, David Heckerman, Nebosja Jojic, Vladimir Jojic, Bruce D. Walker, and James I. Mullins. Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins. PLoS ONE, 2(9):e823, 2007. PubMed ID: 17786195. Show all entries for this paper.


Displaying record number 53897

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location p24(159-168)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country India
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, immunodominance

Notes

References

Thakar2005 Madhuri R. Thakar, Leena S. Bhonge, Samir K. Lakhashe, U. Shankarkumar, Suvarna S. Sane, Smita S. Kulkarni, Bharati A. Mahajan, and Ramesh S. Paranjape. Cytolytic T Lymphocytes (CTLs) from HIV-1 Subtype C-Infected Indian Patients Recognize CTL Epitopes From a Conserved Immunodominant Region of HIV-1 Gag and Nef. J. Infect. Dis., 192(5):749-759, 1 Sep 2005. PubMed ID: 16088824. Show all entries for this paper.


Displaying record number 307

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location p24(287-309)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component p24 Gag

Notes

References

Nakamura1997 Y. Nakamura, M. Kameoka, M. Tobiume, M. Kaya, K. Ohki, T. Yamada, and K. Ikuta. A chain section containing epitopes for cytotoxic T, B and helper T cells within a highly conserved region found in the human immunodeficiency virus type 1 Gag protein. Vaccine, 5:489-96, 1997. PubMed ID: 9160516. Show all entries for this paper.


Displaying record number 58204

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HXB2 Location Gag(291-300)
p24(159-168)
DNA(1660..1689)
Gag Epitope Map
Author Location Gag/Pol(291- CDC-451)
Epitope EPFRDYVDRF Epitope Alignment
EPFRDYVDRF epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen computer prediction
Experimental methods  
Keywords T-cell crossreactivity to human proteins

Notes

References

Lucchese2011 Guglielmo Lucchese, Angela Stufano, Michele Calabro, and Darja Kanduc. Charting the Peptide Crossreactome between HIV-1 and the Human Proteome. Front. Biosci. (Elite Ed.), 3E:1385-1400, 2011. PubMed ID: 21622144. Show all entries for this paper.


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