Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 52873

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HXB2 Location	Gag(74-83) p17(74-83) DNA(1009..1038)	Gag Epitope Map
Author Location	Gag
Epitope	ELRSLYNTVA	Epitope Alignment
Epitope Name	1241
Subtype	multiple
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for ELRSLYNTVA: 71%. This epitope was previously identified in the literature, but was not confirmed in this study.

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.