HIV molecular immunology database
Found 22 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Species (MHC/HLA) | human(A*24) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Subtype | B | |
Species (MHC/HLA) | (B*08) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Other | |
Keywords | epitope processing |
Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | EV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01, A*02 | |
Country | United States | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | rate of progression, escape, mutation acquisition |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Subtype | A1 | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | ML1992: A*02:01, A*30:01, B*08:01, B*44:15, C*02:02, C*04:01.; ML1594: A*01:01, A*30:01, B*08:01, B*42:01, C*07:04, C*17:01 | |
Country | Kenya | |
Experimental methods | Other | |
Keywords | assay or method development |
Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 32645: A*01:01, A*02:01, B*08:01, B*35:03, C*04:01, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Species (MHC/HLA) | human(B*52) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Birk1998 M. Birk, A. Vahlne, A. Sonnerborg, and M. Sallberg. Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 p17 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules. AIDS Res. Hum. Retroviruses, 14:241-248, 1998. PubMed ID: 9491914. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A29, B44, B8, Cw4, Cw7 | |
Country | United States | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A1, B55, B8, Cw3, Cw7 | |
Country | Democratic Republic of the Congo | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Species (MHC/HLA) | (B8) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, vaccine antigen design |
Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82 B1 and B2) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B62, B8, Cw3 | |
Country | Netherlands | |
Experimental methods | Other | |
Keywords | subtype comparisons, computational epitope prediction, superinfection |
Kozaczynska2007 Karolina Kozaczynska, Marion Cornelissen, Peter Reiss, Fokla Zorgdrager, and Antoinette C. van der Kuyl. HIV-1 Sequence Evolution In Vivo after Superinfection with Three Viral Strains. Retrovirology, 4:59, 2007. PubMed ID: 17716368. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9-B08 | |
Subtype | B, F | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | Argentina | |
Experimental methods | ||
Keywords | dynamics, HLA associated polymorphism |
Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Epitope Name | EV9 | |
Species (MHC/HLA) | human(C*06) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(74-82) p17(74-82) DNA(1009..1035) |
Gag Epitope Map |
---|---|---|
Author Location | p17(74-82) | |
Epitope |
ELRSLYNTV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.