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HXB2 Location	Gag(17-31) p17(17-31) DNA(838..882)	Gag Epitope Map
Author Location
Epitope	EKIRLRPGGKKYKL	Epitope Alignment
Species (MHC/HLA)	human(B27, B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, A32, B44, B7; A25, A3, B18, B27
Country	Australia
Experimental methods	CD8 T-cell Elispot - IFNγ, Proliferation
Keywords	rate of progression, elite controllers

Notes

• 13 TAHIV (transfusion acquired HIV) LTNPs were studied longitudinally for up to 27 years to find correlations and indicators of elite control versus delayed progresson to AIDS. 12 of 13 subjects had one or more host genetic factor that coincided with LTNP status, but 50% did not remain non-progressors.
• Immune factors that correlated with LTNP status were very low HIV viremia (<100 copies/ml) associated with Gag p24 proliferative CD4 response. Decline in p24-induced proliferation strongly preceded loss of non-progression to AIDS. Strong Gag-specific CTL responses in one sub-cohort were indicative of control while Pol-specific responses were effective in controlling HIV replication in the other sub-group.
• Peptide 5 (NIH ARRP Cat# 7876), EKIRLRPGGKKYKL, which contains epitopes restricted by HLA-B7 and -B27 elicited the following CTL responses: (1) in a living non-progressor for 19+ years; (2) in another living non-progressor from >1000 sfc/million PBMC at 12.5 years to <1000 sfc/million PBMC at 22+ years.

References

Dyer2008 Wayne B. Dyer, John J. Zaunders, Fang Fang Yuan, Bin Wang, Jennifer C. Learmont, Andrew F. Geczy, Nitin K. Saksena, Dale A. McPhee, Paul R. Gorry, and John S. Sullivan. Mechanisms of HIV Non-Progression; Robust and Sustained CD4+ T-Cell Proliferative Responses to p24 Antigen Correlate with Control of Viraemia and Lack of Disease Progression after Long-Term Transfusion-Acquired HIV-1 Infection. Retrovirology, 5:112, 2008. PubMed ID: 19077215. Show all entries for this paper.