HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 52945

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HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location Gag(260-268)
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 57310

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HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location p24(128-136)
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Epitope Name EL9
Subtype B
Species (MHC/HLA) human(A*24, B*08)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords epitope processing

Notes

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


Displaying record number 53678

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HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location p24
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Subtype B, D
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A24, B35, B58, Cw4, Cw7; M11814: A*23, A*24, B*35, B*58, C*04, C*07
Country Democratic Republic of the Congo
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53244

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HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location Gag(260-268 SUMA)
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Epitope Name Gag EIL9
Subtype B
Species (MHC/HLA) human(A*24:02)
Immunogen HIV-1 infection
Patient MHC/HLA SUMA: A*11:03, A*24:02, B*14:02, B*15:01, C*08:02, C*12:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords dynamics, acute/early infection, autologous responses, optimal epitope

Notes

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.


Displaying record number 62114

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HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location p24(260-268 NL4-3)
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 60933

Download this epitope record as JSON.

HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location p24(128-136)
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Subtype B
Species (MHC/HLA) human(B*08:01)
Immunogen HIV-1 infection
Patient MHC/HLA 67200: A*01:01, A*24:02, B*08:01, B*57:01, C*06:02, C*07:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 57789

Download this epitope record as JSON.

HXB2 Location Gag(260-268)
p24(128-136)
DNA(1567..1593)
Gag Epitope Map
Author Location Gag
Epitope EIYKRWIIL Epitope Alignment
EIYKRWIIL epitope logo
Subtype B
Species (MHC/HLA) human(C*07:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


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