HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 38 matching records:

Displaying record number 57520

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 59605

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59606

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(A*34)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55276

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.


Displaying record number 58193

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name EI8
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58781

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name B*08-EI8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods Other, Tetramer binding
Keywords  

Notes

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.


Displaying record number 58814

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords elite controllers

Notes

References

Ndhlovu2012 Zaza M. Ndhlovu, Jacqueline Proudfoot, Kevin Cesa, Donna Marie Alvino, Ashley McMullen, Seanna Vine, Eleni Stampouloglou, Alicja Piechocka-Trocha, Bruce D. Walker, and Florencia Pereyra. Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses. J. Virol., 86(12):6959-3969, Jun 2012. PubMed ID: 22514340. Show all entries for this paper.


Displaying record number 59604

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57577

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Subtype B
Species (MHC/HLA) (B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 1794

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 60615

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name EI-8
Subtype B
Species (MHC/HLA) human(B*08, B*0801)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 60932

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA 75688: A*0201, A*3201, B*0801, B*5501, Cw*0303, Cw*0701; 44149: A*0101, A*2401, B*0701, B*0801, Cw*0701, Cw*0702; 32645: A*0101, A*0201, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 256

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(260-267 LAI)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61996

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 61477

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name B*08-EI8
Subtype C
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA SK-187: A*3002, A*6802, B*0801, B*5801, Cw*0302, Cw*0701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Koofhethile2016 Catherine K. Koofhethile, Zaza M. Ndhlovu, Christina Thobakgale-Tshabalala, Julia G. Prado, Nasreen Ismail, Zenele Mncube, Lungile Mkhize, Mary van der Stok, Nonhlanhla Yende, Bruce D. Walker, Philip J. R. Goulder, and Thumbi Ndung'u. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J. Virol., 90(15):6818-6831, 1 Aug 2016. PubMed ID: 27194762. Show all entries for this paper.


Displaying record number 59607

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59608

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55515

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 1178

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24( SF2)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1299

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24( SF2)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1408

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.


Displaying record number 1824

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000b P. J. Goulder, Y. Tang, C. Brander, M. R. Betts, M. Altfeld, K. Annamalai, A. Trocha, S. He, E. S. Rosenberg, G. Ogg, C. A. O'Callaghan, S. A. Kalams, R. E. McKinney, Jr., K. Mayer, R. A. Koup, S. I. Pelton, S. K. Burchett, K. McIntosh, and B. D. Walker. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J. Exp. Med., 192(12):1819-32, 18 Dec 2000. URL: http://www.jem.org/cgi/content/full/192/12/1819. PubMed ID: 11120778. Show all entries for this paper.


Displaying record number 52737

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267 IIIB)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords  

Notes

References

Kurane2003 Ichiro Kurane, Kim West, Carmelita U. Tuazon, Weilan Zeng, and Francis A. Ennis. Definition of Two New Epitopes on Human Immunodeficiency Virus Type 1 Gag Protein Recognized by Human CD8+ Cytotoxic T Lymphocyte Clones. J. Clin. Virol., 27(1):38-43, May 2003. PubMed ID: 12727527. Show all entries for this paper.


Displaying record number 52925

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag( B con)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name E18
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.


Displaying record number 53041

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53358

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location ( B consensus)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B62, B8, Cw10, Cw7; A11, A29, B44, B8, Cw4, Cw7; A25, A32, B14, B8, Cw7, Cw8; A1, A3, B14, B8, Cw7, Cw8
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53630

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B35, B8
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 53749

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267 B consensus)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name EI8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A*01, A*11, B*08, B*15, Cw*04, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, variant cross-reactivity, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 54337

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name B8-EI8(p24)
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54536

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(128-135)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name EI8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54805

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


Displaying record number 255

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24(260-267 LAI)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.


Displaying record number 57834

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Epitope Name EI8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 57922

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag(260-267)
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.


Displaying record number 60506

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location p24
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Show epitope variants
Epitope Name B8-EI8
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA ACS 19957: A*01, A*02, B*0801, B*15; ACS 19885: A*01, A*02, B*0801, B*27; ACS 19861: A*01, A*02, B*0801, B*51; ACS 19453: A*01, A*02, B*0801, B*38; ACS 19342: A*01, A*02, B*0801, B*40; ACS 18840: A*02, B*0801, B*27; ACS 18839: A*0207, B*0801, B*27; ACS 18785: A*01, A*02, B*07, B*0801
Country Netherlands
Experimental methods Other, Tetramer binding
Keywords TCR usage

Notes

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 59396

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location Gag
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 55097

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


Displaying record number 54933

HXB2 Location Gag(260-267)
p24(128-135)
DNA(1567..1590)
Gag Epitope Map
Author Location  
Epitope EIYKRWII Epitope Alignment
EIYKRWII epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A1, A2; B38, B8
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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