HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 59603

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(90-98)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54656

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease(34-42 HXB2)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Show epitope variants
Epitope Name EW9
Subtype B
Species (MHC/HLA) human(B18, B40, B44)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, variant cross-reactivity, mutation acquisition, HLA associated polymorphism, drug resistance

Notes

References

Mueller2007 Sandra M. Mueller, Birgit Schaetz, Kathrin Eismann, Silke Bergmann, Michael Bauerle, Matthias Schmitt-Haendle, Hauke Walter, Barbara Schmidt, Klaus Korn, Heinrich Sticht, Bernd Spriewald, Ellen G. Harrer, and Thomas Harrer. Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease. J. Virol., 81(6):2887-2898, Mar 2007. PubMed ID: 17202219. Show all entries for this paper.


Displaying record number 59602

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(90-98)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59297

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 59601

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(90-98)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56384

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease(34-42)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Subtype B
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 52574

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease(34-42)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Species (MHC/HLA) human(B44)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53137

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords epitope processing, supervised treatment interruptions (STI), immunodominance

Notes

References

Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.


Displaying record number 58240

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(90-98)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*4402)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*6801, B*0702, B*4402, Cw*0501, Cw*0702
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 54289

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(2361-)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Species (MHC/HLA) human(B*4402)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 58987

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease(34-42)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Subtype B
Species (MHC/HLA) human(B*4402)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 54400

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol(2355-)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Epitope Name EW9
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 60929

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Protease(34-42)
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Subtype B
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Patient MHC/HLA 11439: A*0101, A*2902, B*3801, B*4403, Cw*1203, Cw*1601; 94153: A*2501, A*6801, B*1402, B*4401, Cw*0501, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 56960

HXB2 Location Pol(90-98)
Protease(34-42)
DNA(2352..2378)
Pol Epitope Map
Author Location Pol
Epitope EEMNLPGRW Epitope Alignment
EEMNLPGRW epitope logo
Subtype C, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health