HIV molecular immunology database
Found 14 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(90-98) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(34-42 HXB2) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | EW9 | |
Subtype | B | |
Species (MHC/HLA) | human(B18, B40, B44) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, variant cross-reactivity, mutation acquisition, HLA associated polymorphism, drug resistance |
Mueller2007 Sandra M. Mueller, Birgit Schaetz, Kathrin Eismann, Silke Bergmann, Michael Bauerle, Matthias Schmitt-Haendle, Hauke Walter, Barbara Schmidt, Klaus Korn, Heinrich Sticht, Bernd Spriewald, Ellen G. Harrer, and Thomas Harrer. Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease. J. Virol., 81(6):2887-2898, Mar 2007. PubMed ID: 17202219. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(90-98) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression |
Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(90-98) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(34-42) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(34-42) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Species (MHC/HLA) | human(B44) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(B44) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | epitope processing, supervised treatment interruptions (STI), immunodominance |
Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(90-98) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B*44:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM33: A*02:01, A*68:01, B*07:02, B*44:02, C*05:01, C*07:02 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | dynamics, escape, acute/early infection, autologous responses, characterizing CD8+ T cells |
Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(2361-) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*44:02) | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, HLA associated polymorphism |
Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(34-42) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*44:02) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(2355-) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Epitope Name | EW9 | |
Species (MHC/HLA) | human(B*44:03) | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, HLA associated polymorphism |
Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(34-42) | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*44:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 11439: A*01:01, A*29:02, B*38:01, B*44:03, C*12:03, C*16:01; 94153: A*25:01, A*68:01, B*14:02, B*44:02, C*05:01, C*08:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(90-98) Protease(34-42) DNA(2352..2378) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
EEMNLPGRW
|
Epitope Alignment
|
Subtype | C, D | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational epitope prediction, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.