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Displaying record number 53161

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HXB2 Location	Pol(358-366) RT(203-211) DNA(3156..3182)	Pol Epitope Map
Author Location	RT
Epitope	EELRQHLLR	Epitope Alignment
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*31:01, A68, B*44:03, B51
Experimental methods
Keywords	HAART, ART, supervised treatment interruptions (STI)

Notes

• T cell immune responses following STI were monitored in two chronically HIV-1 infected partners (A and B) who had contracted HIV-1 during 1992. Both were heterozygous for the CCR5 delta32, and had different HLAs and treatment histories. STI induced strong transitory CD4+ and CD8+ T cell responses in both patients. Patient A displayed broad CD8+ T cell responses directed against Env, Pol, Gag, and Nef HIV-1 antigens. CTL responses in patient B were mainly directed against two epitopes: Gag(p24)NANPDSKTI and Pol(RT)EELRQHLLRW.
• Despite the host differences, both patients had similar dynamics of vial evolution and CD4+ T-cells, suggesting that good immune responses to STI may be more related to the virus than host characteristics in these cases.

References

Arnedo-Valero2004 Mireia Arnedo-Valero, Montserrat Plana, Antonio Mas, Meritxell Guilà, Cristina Gil, Pedro Castro, Felipe Garcia, Esteban Domingo, Josep Ma Gatell, and Tomàs Pumarola. Similar HIV-1 Evolution and Immunological Responses at 10 Years Despite Several Therapeutic Strategies and Host HLA Types. J. Med. Virol., 73(4):495-501, Aug 2004. PubMed ID: 15221891. Show all entries for this paper.