Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 546

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HXB2 Location	Pol(519-527) RT(364-372) DNA(3639..3665)	Pol Epitope Map
Author Location	RT(518-526 U455)
Epitope	DVKQLTEVV	Epitope Alignment
Species (MHC/HLA)	human(A*68:02, A28)
Immunogen
Experimental methods
Keywords	subtype comparisons

Notes

• Predicted on binding motif, no truncations analyzed.
• Reacts with clade A consensus (U455), and with the peptide DVKQLAEAV, from the D clade.

References

Dong1998 T. Dong. Personal Communication, 1998. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Displaying record number 547

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HXB2 Location	Pol(519-527) RT(364-372) DNA(3639..3665)	Pol Epitope Map
Author Location	RT(470-478 subtype A)
Epitope	DVKQLTEVV	Epitope Alignment
		Show epitope variants
Subtype	A
Species (MHC/HLA)	human(B70)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

• CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa.
• This CTL response was defined in a patient with an A subtype infection.
• Bulk cultures from this patient gave a CTL response that could recognize the subtype D form of this epitope, with two substitutions (DVKQLAEAV), though a CTL line from these cultures didn't recognize the B clade variant (DVKQLTEAV)

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.