HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 120

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HXB2 Location Gag(121-132)
p17(121-132)
DNA(1150..1185)
Gag Epitope Map
Author Location p17(121-132 HXB2R)
Epitope DTGHSNQVSQNY Epitope Alignment
DTGHSNQVSQNY epitope logo
Species (MHC/HLA) human(A33)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.


Displaying record number 121

Download this epitope record as JSON.

HXB2 Location Gag(121-132)
p17(121-132)
DNA(1150..1185)
Gag Epitope Map
Author Location Gag(121-132 LAI)
Epitope DTGHSNQVSQNY Epitope Alignment
DTGHSNQVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(A33)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buseyne1993b F. Buseyne, S. Blanche, D. Schmitt, C. Griscelli, and Y. Riviere. Detection of HIV-Specific Cell-Mediated Cytotoxicity in the Peripheral Blood from Infected Children. J. Immunol., 150:3569-3581, 1993. PubMed ID: 8096852. Show all entries for this paper.


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