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Displaying record number 52757

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HXB2 Location	Gag(298-307) p24(166-175) DNA(1681..1710)	Gag Epitope Map
Author Location	Gag(298-307)
Epitope	DRFYKTRAE	Epitope Alignment
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Patient MHC/HLA	A24, A33, B14, B27
Experimental methods	Chromium-release assay
Keywords	TCR usage, genital and mucosal immunity

Notes

• CTL clones from blood, semen, cervix and rectum samples from 12 individuals were compared. CTL clones derived from blood and mucosal samples had similar high lysis efficiency, primarily perforin dependent, and TCRβ VDJ region sequencing revealed cases of expansion of the same clone in different compartments.
• CD8+ T cell clones directed at this epitope were derived from blood and cervix.

References

Musey2003 L. Musey, Y. Ding, J. Cao, J. Lee, C. Galloway, A. Yuen, K. R. Jerome, and M. J. McElrath. Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes. J. Virol., 77(1):291-300, Jan 2003. PubMed ID: 12477834. Show all entries for this paper.