HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 62251

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HXB2 Location Gag(298-307)
p24(166-175)
DNA(1681..1710)
Gag Epitope Map
Author Location p24(298-307 LAI)
Epitope DRFYKTLRAE Epitope Alignment
DRFYKTLRAE epitope logo
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Patient MHC/HLA 15160: A*03, A*32, B*14, B*44
Country United States
Experimental methods Chromium-release assay
Keywords autologous responses, novel epitope

Notes

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.


Displaying record number 331

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HXB2 Location Gag(298-307)
p24(166-175)
DNA(1681..1710)
Gag Epitope Map
Author Location p24(298-306 HX10)
Epitope DRFYKTLRAE Epitope Alignment
DRFYKTLRAE epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA 14279: A*02, A*11, B*13, B*35, C*04, DQ2, DQ7, DR11, DR3, DRw52
Experimental methods  
Keywords immunodominance

Notes

References

Harrer1996 E. Harrer, T. Harrer, P. Barbosa, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of the Highly Conserved YMDD Region in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by HLA-A2-Restricted Cytotoxic T Lymphocytes from an Asymptomatic Long-Term Nonprogresser. J. Infect. Dis., 173:476-479, 1996. The amino acid stretch YMDD is a critical functional domain of reverse transcriptase, and is highly conserved. This sequence is also part of an HLA-A2-restricted epitope. The substitution YMDD to YVDD confers drug resistance to FTC and dideoxyinosine, and also abolishes the CTL specific response. PubMed ID: 8568316. Show all entries for this paper.

Wagner1999 R. Wagner, Y. Shao, and H. Wolf. Correlates of Protection, Antigen Delivery and Molecular Epidemiology: Basics for Designing an HIV Vaccine. Vaccine, 17:1706-1710, 1999. PubMed ID: 10194826. Show all entries for this paper.


Displaying record number 57784

Download this epitope record as JSON.

HXB2 Location Gag(298-307)
p24(166-175)
DNA(1681..1710)
Gag Epitope Map
Author Location p24(166-174)
Epitope DRFYKTLRAE Epitope Alignment
DRFYKTLRAE epitope logo
Show epitope variants
Epitope Name DE-10-1
Species (MHC/HLA) human(B14)
Immunogen in vitro stimulation or selection
Experimental methods Cytotoxicity assay
Keywords dendritic cells

Notes

References

Aldy2011 Kim N. Aldy, Nathan C. Horton, Porunelloor A. Mathew, and Stephen O. Mathew. 2B4+ CD8+ T Cells Play an Inhibitory Role against Constrained HIV Epitopes. Biochem. Biophys. Res. Commun., 405(3):503-507, 18 Feb 2011. PubMed ID: 21256826. Show all entries for this paper.


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