HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 35 matching records:

Displaying record number 319

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 IIIB)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


Displaying record number 320

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 IIIB)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Show epitope variants
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 321

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 HXB2)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords kinetics

Notes

References

Yang1997b O. O. Yang, A. C. Tran, S. A. Kalams, R. P. Johnson, M. R. Roberts, and B. D. Walker. Lysis of HIV-1-Infected Cells and Inhibition of Viral Replication by Universal Receptor T Cells. Proc. Natl. Acad. Sci. U.S.A., 94:11478-11483, 1997. PubMed ID: 9326635. Show all entries for this paper.


Displaying record number 323

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 LAI)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.


Displaying record number 1523

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 SF2)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1845

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24( SF2)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 52111

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Cao2002 Huyen Cao, Deepak Agrawal, Nicholas Kushner, Neal Touzjian, Max Essex, and Yichen Lu. Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J. Infect. Dis., 185(2):244-251, 15 Jan 2002. PubMed ID: 11807699. Show all entries for this paper.


Displaying record number 52427

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B, D
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 52623

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(166-174)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B14, B7, Cw*0702, Cw*0802; A1, A1, B14, B8, Cw7, Cw8
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 53150

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(166-174)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name Gag/p24-DA9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords binding affinity, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 53365

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location ( B consensus)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A29, B14, B44, Cw8; A25, A32, B14, B8, Cw7, Cw8; A3, B14, B60, Cw3, Cw7
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53567

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A29, B14, B44, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53759

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Show epitope variants
Epitope Name DA9
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*68, B*14, B*52, Cw*08, Cw*12
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53784

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) (B14)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 54342

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name B14-DA9(p24)
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54885

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location  
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 325

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Yang1996 O. O. Yang, S. A. Kalams, M. Rosenzweig, A. Trocha, N. Jones, M. Koziel, B. D. Walker, and R. P. Johnson. Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes. J. Virol., 70:5799-5806, 1996. PubMed ID: 8709196. Show all entries for this paper.


Displaying record number 326

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Yang1997 O. O. Yang, S. A. Kalams, A. Trocha, H. Cao, A. Luster, R. P. Johnson, and B. D. Walker. Suppression of Human Immunodeficiency Virus Type 1 Replication by CD8+ Cells: Evidence for HLA Class I-Restricted Triggering of Cytolytic and Noncytolytic Mechanisms. J. Virol., 71:3120-3128, 1997. Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both cytolytic and noncytolytic mechanisms. The predominant mechanism requires direct contact of CTL with the infected cells, is HLA class I restricted, and can achieve complete elimination of detectable virus in infected cell cultures. Inhibition occurs even at high multiplicities of infection or at ratios of CTL to CD4 cells as low as 1:1,000. The other mechanism is mediated by soluble inhibitory factors which are triggered in an antigen-specific and HLA-restricted fashion but then act without HLA restriction. PubMed ID: 9060675. Show all entries for this paper.


Displaying record number 327

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords dendritic cells

Notes

References

Zarling1999 A. L. Zarling, J. G. Johnson, R. W. Hoffman, and D. R. Lee. Induction of Primary Human CD8+ T Lymphocyte Responses In Vitro Using Dendritic Cells. J. Immunol., 162:5197-5204, 1999. PubMed ID: 10227993. Show all entries for this paper.


Displaying record number 330

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 IIIB)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Show epitope variants
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 1184

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24( SF2)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1286

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24( SF2)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1452

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(166-174)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 328

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24( subtype B)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*1402, B14)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 56369

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(398-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 58833

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, elite controllers

Notes

References

Varadarajan2012 Navin Varadarajan, Douglas S. Kwon, Kenneth M. Law, Adebola O. Ogunniyi, Melis N. Anahtar, James M. Richter, Bruce D. Walker, and J. Christopher Love. Rapid, Efficient Functional Characterization and Recovery of HIV-Specific Human CD8+ T Cells Using Microengraving. Proc. Natl. Acad. Sci. U.S.A., 109(10):3885-3890, 6 Mar 2012. PubMed ID: 22355106. Show all entries for this paper.


Displaying record number 59397

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-11: A*33, A*68, B*14, B*15, Cw*02, Cw*08
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 59571

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62117

HXB2 Location Gag(298-306)
p24(166-174)
Gag Epitope Map
Author Location p24(298-306 NL4-3)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) human(B*14)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 58500

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag(298-)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B*14, B*27)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 324

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location p24(298-306 LAI)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human(B*1402)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57859

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location  
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Epitope Name DA9
Species (MHC/HLA) human(B*1402)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 61164

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag(298-306)
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Show epitope variants
Epitope Name DA9
Subtype B
Species (MHC/HLA) human(B*1402)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61332

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 58042

HXB2 Location Gag(298-306)
p24(166-174)
DNA(1681..1707)
Gag Epitope Map
Author Location Gag
Epitope DRFYKTLRA Epitope Alignment
DRFYKTLRA epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*1101, A*3002, B*0702, B*1401, Cw*0702, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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