Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 322

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HXB2 Location	Gag(298-306) p24(166-174) DNA(1681..1707)	Gag Epitope Map
Author Location	p24
Epitope	DRFWKTLRA	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

• A CTL response was found in exposed but uninfected prostitutes from Nairobi using previously-defined B clade epitopes that tended to be conserved in A and D clades -- such cross-reactivity could protect against both A and D and confer protection in Nairobi where both subtypes are circulating.
• The D subtype consensus is identical to the B clade epitope.
• The A subtype consensus is drFfKtLRA.
• Database note: First author "RowlandJones" is also found as "Rowland-Jones" on annotated papers in this database.

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.

Displaying record number 52199

Download this epitope record as JSON.

HXB2 Location	Gag(298-306) p24(166-174) DNA(1681..1707)	Gag Epitope Map
Author Location	p24
Epitope	DRFWKTLRA	Epitope Alignment
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• Neisseria gonorrhea cervititis in 9 HIV+ Kenyan sex workers caused a functional deficiency in IFN-gamma production in HIV-1 epitope-specific CD8+ T-cells, detected by intracellular cytokine production and tetramer assays, while not affecting the total number of epitope-specific CTLs.
• Ghonorrhea caused the weaker HIV-1 specific CTL responses in 4 HIV-1 exposed persistently seronegative (HEPS) women to become undetectable by Elispot and tetramer assays, and CMV-specific CTL in 2 HEPS subjects were shown to have impaired function with regard to IFN-gamma production.

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.