HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 53768

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HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef(86-94 HXB2)
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*03, A*11)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 1009

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HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef(84-92 LAI)
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Subtype B
Species (MHC/HLA) human(A*03:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 52437

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HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Subtype A, B, D, F
Species (MHC/HLA) human, macaque(A*03:01)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 57099

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HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef(86-94 DU422)
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Subtype B
Species (MHC/HLA) human(A*03:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 53017

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HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef(86-94)
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Subtype B
Species (MHC/HLA) human(A*03:01, A11)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 1655

Download this epitope record as JSON.

HXB2 Location Nef(86-94)
DNA(9052..9078)
Nef Epitope Map
Author Location Nef(86-94)
Epitope DLSHFLKEK Epitope Alignment
DLSHFLKEK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


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