Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 479

Download this epitope record as JSON.

HXB2 Location	Pol(347-356) RT(192-201) DNA(3123..3152)	Pol Epitope Map
Author Location	RT(192-201)
Epitope	DLEIGQHRTK	Epitope Alignment
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Of 98 patients in cross-sectional analysis, 78% had CTL against pol -- RT was more immunogenic than Integrase and Protease (81%, 51%, and 24% of 37 patients, respectively)
• New clusters of epitopes were defined utilizing different HLA molecules.

References

Haas1998 G. Haas, A. Samri, E. Gomard, A. Hosmalin, J. Duntze, J. M. Bouley, H. G. Ihlenfeldt, C. Katlama, and B. Autran. Cytotoxic T Cell Responses to HIV-1 Reverse Transcriptase, Integrase and Protease. AIDS, 12(12):1427-1436, 1998. PubMed ID: 9727563. Show all entries for this paper.

Displaying record number 52987

Download this epitope record as JSON.

HXB2 Location	Pol(347-356) RT(192-201) DNA(3123..3152)	Pol Epitope Map
Author Location	Pol(192-201)
Epitope	DLEIGQHRTK	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8
Country	Netherlands
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, escape

Notes

• Both stable potential epitopes and epitopes with escape mutations were found in a patient with increasing viral load over a time period of 4 years. Fixation of escape mutations occurred sequentially and correlated with the rise in viral load and with the increased number of productively infected cells.
• This is one of 7 epitopes from this individual that varied over time, although the internal mutations did not become fixed. The dleMgqhrtk variant arose at late time points.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.