Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 52857

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HXB2 Location	Vif(101-110) DNA(5341..5370)	Vif Epitope Map
Author Location	Vif
Epitope	DLADQLIHLY	Epitope Alignment
Epitope Name	1237
Subtype	multiple
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	902991: A2, A30, B39; H0014M: A*01, A*02, B*08
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for DLADQLIHLY: 54%

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.