Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 54770

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HXB2 Location	Gag(425-435) p2p7p1p6(62-72) DNA(2062..2094)	Gag Epitope Map
Author Location	Gag(426-436)
Epitope	DCTERQANFLG	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	India
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	subtype comparisons

Notes

• T cell responses to Gag consensus C peptides were studied in C-infected patients from India. CD8+ responses were stronger and broader than CD4+ responses. IFN-γ response was higher than corresponding IL-2 response in both CD8+ and CD4+ T cells.
• 3/25 patients responded to this peptide (IFN-γ CD8+ response). An IL-2 response was not detectable.

References

Kaushik2005 S. Kaushik, M. Vajpayee, N. Wig, and P. Seth. Characterization of HIV-1 Gag-Specific T Cell Responses in Chronically Infected Indian Population. Clin. Exp. Immunol., 142(2):388-397, Nov 2005. PubMed ID: 16232229. Show all entries for this paper.

Displaying record number 55776

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HXB2 Location	Gag(425-435) p2p7p1p6(62-72) DNA(2062..2094)	Gag Epitope Map
Author Location	Gag(425-435)
Epitope	DCTERQANFLG	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, vaccine
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords

Vaccine Details

Notes

• To check whether unsuccessful vaccines may interfere with normal patient immune response,2 subjects were followed. The first, 00015, was seronegative while receiving vaccination, but later contracted infection. The second, 00016, had temporary sexual contact with subject 00015 and showed symptoms of disease 2 weeks before him. Without treatment, both reached low chronic viremic levels, and showed similar magnitude of immune response.
• Similar immune pressure was seen on viral sequences in both patients, over time in Gag, Pol, Nef.
• Data suggest that the vaccine failed to prime subject 00015 against HIV infection, but it did not impair ability to naturally contain viremia in comparison with infecting subject 00016.
• CTL immune response to consensus sequence DCTERQANFLG was elicited in subject 00016. Consensus epitope of subjects were the same as Clade B consensus.

References

Balamurugan2008 Arumugam Balamurugan, Martha J. Lewis, Christina M. R. Kitchen, Michael N. Robertson, John W. Shiver, Eric S. Daar, Jacqueline Pitt, Ayub Ali, Hwee L. Ng, Judith S. Currier, and Otto O. Yang. Primary Human Immunodeficiency Virus Type 1 (HIV-1) Infection during HIV-1 Gag Vaccination. J. Virol., 82(6):2784-2791, Mar 2008. PubMed ID: 18199650. Show all entries for this paper.