HIV molecular immunology database
Found 22 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(197-205) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(197-205) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337 NL4-3) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*08) | |
Immunogen | computer prediction | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | vaccine antigen design, viral fitness and reversion |
Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337 LAI) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Subtype | A1 | |
Species (MHC/HLA) | human(B*08:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | ML1992: A*02:01, A*30:01, B*08:01, B*44:15, C*02:02, C*04:01.; ML1857: A*02:01, A*66:01, B*35:01, B*44:18, C*04:01, C*16:04 | |
Country | Kenya | |
Experimental methods | Other | |
Keywords | assay or method development |
Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Species (MHC/HLA) | human(B*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | (B8) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, vaccine antigen design |
Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337 LAI) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Sutton1993 J. Sutton, S. Rowland-Jones, W. Rosenberg, D. Nixon, F. Gotch, X.-M. Gao, N. Murray, A. Spoonas, P. Driscoll, M. Smith, A. Willis, and A. McMichael. A Sequence Pattern for Peptides Presented to Cytotoxic T Lymphocytes by HLA B8 Revealed by Analysis of Epitopes and Eluted Peptides. Eur. J. Immunol., 23:447-453, 1993. PubMed ID: 7679646. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | escape |
Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | ||
Experimental methods | ||
Keywords |
McAdam1995 S. McAdam, P. Klenerman, L. Tussey, S. Rowland-Jones, D. Lalloo, R. Phillips, A. Edwards, P. Giangrande, A. L. Brown, and F. Gotch. Immunogenic HIV Variant Peptides That Bind to HLA-B8 Can Fail to Stimulate Cytotoxic T Lymphocyte Responses. J. Immunol., 155:2729-2736, 1995. PubMed ID: 7544382. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(197-205) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DCK | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection |
Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(197-205) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DCK | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Species (MHC/HLA) | humanized rabbit(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A28, A3, B7, B8 | |
Country | Canada | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, memory cells |
Gamberg2004 Jane Gamberg, Lisa Barrett, Ian Bowmer, Constance Howley, and Michael Grant. Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection. J. Clin. Immunol., 24(2):115-124, Mar 2004. PubMed ID: 15024178. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | DL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B14, B8, Cw7, Cw8 | |
Country | United States | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Epitope Name | B8-DL9(p24) | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(329-337) p24(197-205) DNA(1774..1800) |
Gag Epitope Map |
---|---|---|
Author Location | p24(329-337) | |
Epitope |
DCKTILKAL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.