HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 22 matching records:

Displaying record number 1795

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(197-205)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 56368

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 58537

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(197-205)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 59566

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62119

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337 NL4-3)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 353

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337 LAI)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Subtype B
Species (MHC/HLA) human(B*08:01)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58432

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Subtype A1
Species (MHC/HLA) human(B*08:01)
Immunogen HIV-1 infection
Patient MHC/HLA ML1992: A*02:01, A*30:01, B*08:01, B*44:15, C*02:02, C*04:01.; ML1857: A*02:01, A*66:01, B*35:01, B*44:18, C*04:01, C*16:04
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 59565

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59564

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Species (MHC/HLA) human(B*15:03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59567

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Species (MHC/HLA) human(B*35:02, B*35:03, B*53:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54809

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location  
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


Displaying record number 352

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337 LAI)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Sutton1993 J. Sutton, S. Rowland-Jones, W. Rosenberg, D. Nixon, F. Gotch, X.-M. Gao, N. Murray, A. Spoonas, P. Driscoll, M. Smith, A. Willis, and A. McMichael. A Sequence Pattern for Peptides Presented to Cytotoxic T Lymphocytes by HLA B8 Revealed by Analysis of Epitopes and Eluted Peptides. Eur. J. Immunol., 23:447-453, 1993. PubMed ID: 7679646. Show all entries for this paper.


Displaying record number 354

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


Displaying record number 355

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

McAdam1995 S. McAdam, P. Klenerman, L. Tussey, S. Rowland-Jones, D. Lalloo, R. Phillips, A. Edwards, P. Giangrande, A. L. Brown, and F. Gotch. Immunogenic HIV Variant Peptides That Bind to HLA-B8 Can Fail to Stimulate Cytotoxic T Lymphocyte Responses. J. Immunol., 155:2729-2736, 1995. PubMed ID: 7544382. Show all entries for this paper.


Displaying record number 356

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(197-205)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.


Displaying record number 1374

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DCK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1451

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(197-205)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 52320

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DCK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52965

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location Gag(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Species (MHC/HLA) humanized rabbit(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A3, B7, B8
Country Canada
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, memory cells

Notes

References

Gamberg2004 Jane Gamberg, Lisa Barrett, Ian Bowmer, Constance Howley, and Michael Grant. Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection. J. Clin. Immunol., 24(2):115-124, Mar 2004. PubMed ID: 15024178. Show all entries for this paper.


Displaying record number 53381

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location ( B consensus)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name DL9
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B14, B8, Cw7, Cw8
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 54341

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Epitope Name B8-DL9(p24)
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 62825

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HXB2 Location Gag(329-337)
p24(197-205)
DNA(1774..1800)
Gag Epitope Map
Author Location p24(329-337)
Epitope DCKTILKAL Epitope Alignment
DCKTILKAL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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