Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55341

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HXB2 Location	Vif(61-69) DNA(5221..5247)	Vif Epitope Map
Author Location	Vif
Epitope	DAKLIITTY	Epitope Alignment
Epitope Name	Vif-DY9
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02, A*03, B*35, B*51
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, acute/early infection, memory cells

Notes

• CD127 hi memory CTLs were correlated with different patient groups - subjects with chronic HIV-1 infection or controllers or those treated early with ART. For patients with chronic infection, CD127 hi CTL levels decrease greatly. Early ART treatment alone maintained these long-lived memory T cells.
• In response to epitope DY9, DAKLIITTY, a patient with oscillating ART had IFN-gamma secretion by CD127 lo cells during viremia and CD127hi cell-IFN-gamma production during viremic control. Shortly after ART cessation, CD127 mixed cells secreted IFN-gamma. HLA-restriction is to -B*35.

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.

Displaying record number 53597

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HXB2 Location	Vif(61-69) DNA(5221..5247)	Vif Epitope Map
Author Location	Vif(61-69)
Epitope	DAKLIITTY	Epitope Alignment
		Show epitope variants
Epitope Name	DY9
Subtype	B
Species (MHC/HLA)	human(B*35:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	8183A: A*02:01, A*03:01, B*35:01, B*51, C*04, C*06
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords	dynamics, escape, acute/early infection

Notes

• Patients with acute or early infection were shown to preferentially target variable peptides with higher entropy while those with chronic infection showed responses towards more conserved peptides with lower entropy. In longitudinally followed subjects, responses to variable proteins declined over time while responses to conserved proteins increased. The decline is suggested to be due to CTL escape.
• The peptide that carries this epitope DAKLIITTY, B35-DG15 DAKLVITTYWGLHTG (aa 61–75), was recognized early in infection but the response diminished over time. A point mutation of epitope position 7 (T to K, DAKLIIkTY) was detected at high frequency at a chronic infection timepoint, 34 months. The K variant was an escape form, and had low avidity by gamma IFN EliSpot.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.