Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 52889

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HXB2 Location	gp160(296-305) gp120(296-305) DNA(7110..7139)	gp160 Epitope Map
Author Location	Env
Epitope	CTRPNNNTRK	Epitope Alignment
Epitope Name	1265
Subtype	multiple
Species (MHC/HLA)	human(A2, A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A23, A3, B49, B57
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, HLA cross-presentation, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for CTRPNNNTRK: 51% Promiscuous epitope binding to A02 and A03.

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.

Displaying record number 55135

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HXB2 Location	gp160(296-305) gp120(296-305) DNA(7110..7139)	gp160 Epitope Map
Author Location	gp120(296-305)
Epitope	CTRPNNNTRK	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(A2, A3)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

• Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
• Present in 283/515 Brazilian HIV sequences; a common variant is CTRPgNNTRK found in subtype B sequences.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.

Displaying record number 55235

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HXB2 Location	gp160(296-305) gp120(296-305) DNA(7110..7139)	gp160 Epitope Map
Author Location	Env(296-305 B1 and B2)
Epitope	CTRPNNNTRK	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A3, A32, B62, B8, Cw3
Country	Netherlands
Experimental methods	Other
Keywords	subtype comparisons, computational epitope prediction, superinfection

Notes

• The influence of superinfection upon changes in HIV-1 strains was studied in a triple infected subject. While continuous expression of all three strains was observed, the LTR promoters of subtype AE had highest activity of all 3 strains, and subtype B2 had the lowest. Env-V3 sequences were present in higher numbers in strains B2 and CRF01_AE. Recombination was seen between viruses B1/B2 in gag and vpr genes.
• This HLA-A03 restricted epitope, CTRPNNNTRK, varied to CTRPsNNTRK in B1 and B2, and CTRPsNNTRt in AE by the earliest time point taken, with no changes over time.

References

Kozaczynska2007 Karolina Kozaczynska, Marion Cornelissen, Peter Reiss, Fokla Zorgdrager, and Antoinette C. van der Kuyl. HIV-1 Sequence Evolution In Vivo after Superinfection with Three Viral Strains. Retrovirology, 4:59, 2007. PubMed ID: 17716368. Show all entries for this paper.