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Found 2 matching records:

Displaying record number 689

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HXB2 Location gp160(239-247)
gp120(239-247)
DNA(6939..6965)
gp160 Epitope Map
Author Location gp120(241-249 LAI)
Epitope CTNVSTVQC Epitope Alignment
CTNVSTVQC epitope logo
Subtype B
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 55294

Download this epitope record as JSON.

HXB2 Location gp160(239-247)
gp120(239-247)
DNA(6939..6965)
gp160 Epitope Map
Author Location Env
Epitope CTNVSTVQC Epitope Alignment
CTNVSTVQC epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*35:01, B44, C*16, Cw7; A*02:01, A19, B14, B44, C*16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


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