HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 56204

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HXB2 Location gp160(205-213)
gp120(205-213)
DNA(6837..6863)
gp160 Epitope Map
Author Location Env(250-)
Epitope CPKVSFEPI Epitope Alignment
CPKVSFEPI epitope logo
Species (MHC/HLA) human(B*07:02)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 62865

Download this epitope record as JSON.

HXB2 Location gp160(205-213)
gp120(205-213)
DNA(6837..6863)
gp160 Epitope Map
Author Location Env( JR-CSF)
Epitope CPKVSFEPI Epitope Alignment
CPKVSFEPI epitope logo
Show epitope variants
Epitope Name CI9
Subtype B
Species (MHC/HLA) humanized mouse(B*07:02)
Immunogen HIV-1 infection, vaccine, virus
Experimental methods Cytokine production, IVAG challenge, Other, T-cell Elispot
Keywords vaccine-induced immune responses, escape, assay or method development

Vaccine Details

Vaccine type virus, PLG microparticle, recombinant protein
Vaccine strain B clade
Vaccine component Gag, virus

Notes

References

Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.


Displaying record number 56547

Download this epitope record as JSON.

HXB2 Location gp160(205-213)
gp120(205-213)
DNA(6837..6863)
gp160 Epitope Map
Author Location Env
Epitope CPKVSFEPI Epitope Alignment
CPKVSFEPI epitope logo
Epitope Name Env250
Subtype B
Species (MHC/HLA) human(B7)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 56526

Download this epitope record as JSON.

HXB2 Location gp160(205-213)
gp120(205-213)
DNA(6837..6863)
gp160 Epitope Map
Author Location Env
Epitope CPKVSFEPI Epitope Alignment
CPKVSFEPI epitope logo
Epitope Name Env250
Subtype A, B, D
Species (MHC/HLA) human, mouse(B7 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


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