HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 59561

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Epitope Name CC8
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59562

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Epitope Name CC8
Species (MHC/HLA) human(C*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59560

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Epitope Name CC8
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57173

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location  
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Subtype B
Species (MHC/HLA) human(Cw12)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, acute/early infection

Notes

References

Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.


Displaying record number 52611

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Species (MHC/HLA) human(Cw*12)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53476

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Show epitope variants
Epitope Name CC8
Subtype B
Species (MHC/HLA) human(Cw*12)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 53530

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Epitope Name CC8
Subtype B
Species (MHC/HLA) human(Cw*12)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53789

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Epitope Name CC8
Species (MHC/HLA) (Cw*12)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 59089

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 58146

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Show epitope variants
Epitope Name CC8
Subtype B
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58991

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Subtype B
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 52639

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Patient MHC/HLA A26, A3, B*3801, B7, Cw*0702, Cw*1203; A*0201, A*2501, B18, B51, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early treatment

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 54159

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37 HXB2)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Show epitope variants
Epitope Name CC8
Subtype B
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 52640

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location Tat(30-37)
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Species (MHC/HLA) human(Cw*1203)
Immunogen HIV-1 infection
Patient MHC/HLA A26, A3, B*3801, B7, Cw*0702, Cw*1203; A*0201, A*2501, B18, B51, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early treatment

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 54925

HXB2 Location Tat(30-37)
DNA(5918..5941)
Tat Epitope Map
Author Location  
Epitope CCFHCQVC Epitope Alignment
CCFHCQVC epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*2501, A*3002; B*0702, B*1801
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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