HIV molecular immunology database
Found 15 matching records:
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Epitope Name | CC8 | |
Species (MHC/HLA) | human(B*18) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Epitope Name | CC8 | |
Species (MHC/HLA) | human(C*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Epitope Name | CC8 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Epitope Name | CC8 | |
Species (MHC/HLA) | (C*12) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion |
Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*12) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | CC8 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | escape |
Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | ||
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | immunodominance, acute/early infection |
Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Epitope Name | CC8 | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A26, A3, B*38:01, B7, C*07:02, C*12:03; A*02:01, A*25:01, B18, B51, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection, early treatment |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | CC8 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection |
Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion |
Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A26, A3, B*38:01, B7, C*07:02, C*12:03; A*02:01, A*25:01, B18, B51, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection, early treatment |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | Tat(30-37 HXB2) | |
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | CC8 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition, optimal epitope |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Tat(30-37) DNA(5918..5941) |
Tat Epitope Map |
---|---|---|
Author Location | ||
Epitope |
CCFHCQVC
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 014A-005: A*25:01, A*30:02, B*07:02, B*18:01, C*07:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | canarypox prime with gp120 boost |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | Gag-Pol, gp120, gp41 |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.