HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 61153

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location  
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Subtype B
Species (MHC/HLA) human, mouse(A*02:06)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61507

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag(341-349)
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name GagAA9
Subtype B
Species (MHC/HLA) human(A*02:06)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords optimal epitope, chronic infection

Notes

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


Displaying record number 61546

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location p24(207-219)
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name Gag AA9
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*02:06)
Immunogen HIV-1 infection
Patient MHC/HLA KI-648: A*02:06
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords optimal epitope, chronic infection

Notes

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.


Displaying record number 61789

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location  
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name AA9
Subtype B
Species (MHC/HLA) human(A*02:06)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 54207

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Subtype CRF01_AE
Species (MHC/HLA) human(A*02:06)
Immunogen HIV-1 infection
Country Thailand
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords optimal epitope

Notes

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.


Displaying record number 61883

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location  
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Show epitope variants
Epitope Name Gag AA9
Subtype B
Species (MHC/HLA) human(A*02:06)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA KI-611: A*02:06
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, viral replication

Notes

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


Displaying record number 52681

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag(341-)
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name Gag341
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component p24 Gag
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 55369

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location  
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name Gag 341
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55889

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HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Subtype B, D
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons

Notes

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.


Displaying record number 56058

Download this epitope record as JSON.

HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag(341-)
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Epitope Name Gag341
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 58947

Download this epitope record as JSON.

HXB2 Location Gag(341-349)
p24(209-217)
DNA(1810..1836)
Gag Epitope Map
Author Location Gag
Epitope ATLEEMMTA Epitope Alignment
ATLEEMMTA epitope logo
Subtype A
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Kenya, Pakistan
Experimental methods Other
Keywords epitope processing

Notes

References

Abidi2013 Syed H. Abidi, Aniqa Shahid, Laila S. Lakhani, Muhammad R. Khanani, Peter Ojwang, Nancy Okinda, Reena Shah, Farhat Abbas, Sarah Rowland-Jones, and Syed Ali. Population-Specific Evolution of HIV Gag Epitopes in Genetically Diverged Patients. Infect. Genet. Evol., 16:78-86, Jun 2013. PubMed ID: 23403357. Show all entries for this paper.


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