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Displaying record number 56091

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HXB2 Location	Gag(457-465) p2p7p1p6(94-102) DNA(2158..2184)	Gag Epitope Map
Author Location	Gag
Epitope	APPAESFRF	Epitope Alignment
Epitope Name	Gag1147
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

• 45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
• Novel Gag epitope APPAESFRF elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.