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Displaying record number 52792

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HXB2 Location	Gag(197-205) p24(65-73) DNA(1378..1404)	Gag Epitope Map
Author Location	p24(197-205)
Epitope	AMQMLKETI?	Epitope Alignment
Species (MHC/HLA)	mouse
Immunogen	vaccine
Patient MHC/HLA	H-2d
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords	TCR usage, genital and mucosal immunity

Vaccine Details

Notes

• Intranasal immunization triggered CTL response in the nasal-associated lymphoid tissue (NALT), posterior cervical lymph nodes (pCLNs) and the spleen, but not in the mesenteric lymph nodes (MLNs). Rectal immunization elicited CTL responses only in the MLNs. By immunizing mice nasally following rectal immunization, CTL responses were detected in NALT, pCLNs, spleen and MLNs. Epitope-specific CD8+ T-cells were primarily located in NALT after 6 days and in pCLNs after 2 months.
• The strongest specific lysis was induced by NALT-specific CTL clones. pCLNs derived memory CTL clones originated from NALT CTL clones, as determined by T-cell receptor Vβ usage.

References

Yoshizawa2003 Izumi Yoshizawa, Toshiaki Mizuochi, Akio Ogata, Masahiro Murakami, Hideo Yagita, Yoshimasa Takahashi, Tsuguo Mizuochi, Toshitada Takemori, Yasuko Tsunetsugu-Yokota, and Hideo Yagaita. Studies on the Generation and Maintenance of Mucosal Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Gag in Mice. AIDS Res. Hum. Retroviruses, 19(6):469-479, Jun 2003. PubMed ID: 12882656. Show all entries for this paper.