HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 57936

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location  
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Show epitope variants
Epitope Name G1
Subtype A
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, HLA binding, Intracellular cytokine staining
Keywords immunodominance, vaccine antigen design, optimal epitope

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, other

Notes

References

Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.


Displaying record number 61035

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Subtype C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production
Keywords vaccine-induced immune responses, vaccine antigen design

Notes

References

Chapman2013 Rosamund Chapman, Helen Stutz, William Jacobs, Jr., Enid Shephard, and Anna-Lise Williamson. Priming with Recombinant Auxotrophic BCG Expressing HIV-1 Gag, RT and Gp120 and Boosting with Recombinant MVA Induces a Robust T Cell Response in Mice. PLoS One, 8(8):e71601, 20 Aug 2013. PubMed ID: 23977084. Show all entries for this paper.


Displaying record number 55324

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Show epitope variants
Epitope Name G
Subtype A, B, C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, antagonism

Vaccine Details

Vaccine type DNA with CMV promotor, modified vaccinia Ankara (MVA), DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade, B clade, C clade Du422, other
Vaccine component Gag, Nef, RT

Notes

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 56263

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location  
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Subtype C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Country South Africa
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, Th1

Vaccine Details

Vaccine type DNA, DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain C clade Du422, C clade Du151
Vaccine component Gag, gp160 deletions, Nef, RT, Tat

Notes

References

Shephard2008 Enid Shephard, Wendy A. Burgers, Joanne H. Van Harmelen, James E. Monroe, Trish Greenhalgh, Carolyn Williamson, and Anna-Lise Williamson. A Multigene HIV Type 1 Subtype C Modified Vaccinia Ankara (MVA) Vaccine Efficiently Boosts Immune Responses to a DNA Vaccine in Mice. AIDS Res. Hum. Retroviruses, 24(2):207-217, Feb 2008. PubMed ID: 18240963. Show all entries for this paper.


Displaying record number 54995

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag( C-96BW04.09)
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Epitope Name A
Subtype C
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, alphavirus replicon
Vaccine strain C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component Gag, Gag-Pol, Pol

Notes

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.


Displaying record number 62014

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Subtype B, BC, C, CRF01_AE
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA)
Vaccine component Gag

Notes

References

Liu2018 Wan Liu, Yik Chun Wong, Samantha M. Y. Chen, Jiansong Tang, Haibo Wang, Allen Ka Loon Cheung, and Zhiwei Chen. DNA Prime/MVTT Boost Regimen with HIV-1 Mosaic Gag Enhances the Potency of Antigen-Specific Immune Responses. Vaccine, 36(31):4621-4632, 25 Jul 2018. PubMed ID: 29961605. Show all entries for this paper.


Displaying record number 55841

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Epitope Name Gag A-I
Subtype BC
Species (MHC/HLA) human
Immunogen vaccine
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost
Vaccine strain other
Vaccine component Env, Gag, Nef, Pol, Tat

Notes

References

Huang2008 Yaoxing Huang, Zhiwei Chen, Wenyong Zhang, Deborah Gurner, Yang Song, David F. Gardiner, and David D. Ho. Design, Construction, and Characterization of a Dual-Promoter Multigenic DNA Vaccine Directed against an HIV-1 Subtype C/B' Recombinant. J. Acquir. Immune Defic. Syndr., 47(4):403-411, 1 Apr 2008. PubMed ID: 18209683. Show all entries for this paper.


Displaying record number 61128

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Epitope Name Gag AI
Subtype B, C
Species (MHC/HLA) mouse
Immunogen vaccine
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine component Gag-Pol, Nef-Tat, ΔV2Env

Notes

References

Chen2008b Zhiwei Chen, Yaoxing Huang, Xiuqing Zhao, Lei Ba, Wenyong Zhang, and David D. Ho. Design, Construction, and Characterization of a Multigenic Modified Vaccinia Ankara Candidate Vaccine against Human Immunodeficiency Virus Type 1 subtype C/B'. J. Acquir. Immune Defic. Syndr., 47(4):412-421, 1 Apr 2008. PubMed ID: 18209682. Show all entries for this paper.


Displaying record number 61138

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location  
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human, mouse
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 52785

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HXB2 Location Gag(197-205)
p24(65-73)
DNA(1378..1404)
Gag Epitope Map
Author Location Gag( Du422)
Epitope AMQMLKDTI Epitope Alignment
AMQMLKDTI epitope logo
Subtype C
Species (MHC/HLA) mouse
Immunogen vaccine
Patient MHC/HLA H-2d
Experimental methods Chromium-release assay
Keywords subtype comparisons, variant cross-reactivity

Vaccine Details

Vaccine type DNA
Vaccine strain C clade Du422
Vaccine component Gag

Notes

References

vanHarmelen2003 Joanne H van Harmelen, Enid Shephard, Robin Thomas, Tomas Hanke, Anna Lise Williamson, and Carolyn Williamson. Construction and Characterisation of a Candidate HIV-1 Subtype C DNA Vaccine for South Africa. Vaccine, 21(27-28):4380-9, Oct 2003. PubMed ID: 14505921. Show all entries for this paper.


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