HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 54570

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA A*01, B*08
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 1766

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 57327

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 53794

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name A9M
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Vaccine type measles virus (MV)
Vaccine strain multiple epitope immunogen
Vaccine component gp140, gp140ΔV3

Notes

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.


Displaying record number 1103

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41 LAI)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53440

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol(132-140 IIIB)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Show epitope variants
Epitope Name pol132-140
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods Intracellular cytokine staining
Keywords subtype comparisons, vaccine-induced immune responses, immunodominance, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component Gag-Pol

Notes

References

Singh2004 Rana A K Singh and Michael A Barry. Repertoire and Immunofocusing of CD8 T Cell Responses Generated by HIV-1 gag-pol and Expression Library Immunization Vaccines. J. Immunol., 173(7):4387-4393, 1 Oct 2004. PubMed ID: 15383568. Show all entries for this paper.


Displaying record number 53003

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41 MN)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain B clade MN
Vaccine component gp120, Protease, RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.


Displaying record number 409

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Haas1998 G. Haas, A. Samri, E. Gomard, A. Hosmalin, J. Duntze, J. M. Bouley, H. G. Ihlenfeldt, C. Katlama, and B. Autran. Cytotoxic T Cell Responses to HIV-1 Reverse Transcriptase, Integrase and Protease. AIDS, 12(12):1427-1436, 1998. PubMed ID: 9727563. Show all entries for this paper.


Displaying record number 53573

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 53814

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords  

Notes

References

Mason2005 R. D. Mason, M. I. Bowmer, C. M. Howley, and M. D. Grant. Cross-Reactive Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Protease and Gamma Interferon-Inducible Protein 30. J. Virol., 79(9):5529-5536, May 2005. PubMed ID: 15827167. Show all entries for this paper.


Displaying record number 54237

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name A2-AM9(RT)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55286

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*3501, B44, Cw16, Cw7; A*0201, A19, B14, B44, Cw16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


Displaying record number 56420

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name AM9(RT)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 57625

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location  
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name ALV
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 53052

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location RT(33-41)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2, A3)
Immunogen HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, immunotherapy, variant cross-reactivity

Notes

References

Mason2004 Rosemarie D. Mason, M. Ian Bowmer, Constance M. Howley, Maureen Gallant, Jennifer C. E. Myers, and Michael D. Grant. Antiretroviral Drug Resistance Mutations Sustain or Enhance CTL Recognition of Common HIV-1 Pol Epitopes. J. Immunol., 172(11):7212-7219, 1 Jun 2004. PubMed ID: 15153547. Show all entries for this paper.


Displaying record number 59541

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol(188-196)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name AM9
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59542

HXB2 Location Pol(188-196)
RT(33-41)
DNA(2646..2672)
Pol Epitope Map
Author Location Pol(188-196)
Epitope ALVEICTEM Epitope Alignment
ALVEICTEM epitope logo
Epitope Name AM9
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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