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Displaying record number 1466

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HXB2 Location	Pol(188-196) RT(33-41) DNA(2646..2672)	Pol Epitope Map
Author Location	RT(33-41 LAI)
Epitope	ALVEICTEL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, computational epitope prediction

Notes

• This epitope contains the mutation M41L, a mutation induced by nucleosidee reverse transcriptase inhibitors.
• Patient 201#5, (A*0201), was found by ELISPOT to recognize the mutated peptide after Zidovudine treatment, but not the wild-type peptide -- the mutation M41L gave an increased A2 binding score (http://bimas.dcrt.nih.gov/molbio/hla_bind) compared to the wildtype RT sequence.
• Three additional A*0201 individuals and one B27 individual did not respond to this epitope before or after treatment.
• M41L occurred at anchor positions p2 and p9 in several computer predicted RT epitopes (33-41, 32-41, and 40-49) (http//bimas.dcrt.nih.gov/molbio/hla_bind), and increased the predicted binding affinity for 6 HLA molecules (B2705, B5102, C3, A0201, B2705 and B3901)

References

Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.